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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

Haiman, Christopher A. (author)
Chen, Gary K. (author)
Vachon, Celine M. (author)
show more...
Canzian, Federico (author)
Dunning, Alison (author)
Millikan, Robert C. (author)
Wang, Xianshu (author)
Ademuyiwa, Foluso (author)
Ahmed, Shahana (author)
Ambrosone, Christine B. (author)
Baglietto, Laura (author)
Balleine, Rosemary (author)
Bandera, Elisa V. (author)
Beckmann, Matthias W. (author)
Berg, Christine D. (author)
Bernstein, Leslie (author)
Blomqvist, Carl (author)
Blot, William J. (author)
Brauch, Hiltrud (author)
Buring, Julie E. (author)
Carey, Lisa A. (author)
Carpenter, Jane E. (author)
Chang-Claude, Jenny (author)
Chanock, Stephen J. (author)
Chasman, Daniel I. (author)
Clarke, Christine L. (author)
Cox, Angela (author)
Cross, Simon S. (author)
Deming, Sandra L. (author)
Diasio, Robert B. (author)
Dimopoulos, Athanasios M. (author)
Driver, W. Ryan (author)
Duennebier, Thomas (author)
Durcan, Lorraine (author)
Eccles, Diana (author)
Edlund, Christopher K. (author)
Ekici, Arif B. (author)
Fasching, Peter A. (author)
Feigelson, Heather S. (author)
Flesch-Janys, Dieter (author)
Fostira, Florentia (author)
Försti, Asta (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
Fountzilas, George (author)
Gerty, Susan M. (author)
Karolinska Institutet
Giles, Graham G. (author)
Godwin, Andrew K. (author)
Goodfellow, Paul (author)
Graham, Nikki (author)
Greco, Dario (author)
Hamann, Ute (author)
Hankinson, Susan E. (author)
Hartmann, Arndt (author)
Hein, Rebecca (author)
Heinz, Judith (author)
Holbrook, Andrea (author)
Hoover, Robert N. (author)
Hu, Jennifer J. (author)
Hunter, David J. (author)
Ingles, Sue A. (author)
Irwanto, Astrid (author)
Ivanovich, Jennifer (author)
John, Esther M. (author)
Johnson, Nicola (author)
Jukkola-Vuorinen, Arja (author)
Kaaks, Rudolf (author)
Ko, Yon-Dschun (author)
Kolonel, Laurence N. (author)
Konstantopoulou, Irene (author)
Kosma, Veli-Matti (author)
Kulkarni, Swati (author)
Lambrechts, Diether (author)
Lee, Adam M. (author)
Le Marchand, Loic (author)
Lesnick, Timothy (author)
Liu, Jianjun (author)
Lindstrom, Sara (author)
Mannermaa, Arto (author)
Margolin, Sara (author)
Martin, Nicholas G. (author)
Miron, Penelope (author)
Montgomery, Grant W. (author)
Nevanlinna, Heli (author)
Nickels, Stephan (author)
Nyante, Sarah (author)
Olswold, Curtis (author)
Palmer, Julie (author)
Pathak, Harsh (author)
Pectasides, Dimitrios (author)
Perou, Charles M. (author)
Peto, Julian (author)
Pharoah, Paul D. P. (author)
Pooler, Loreall C. (author)
Press, Michael F. (author)
Pylkas, Katri (author)
Rebbeck, Timothy R. (author)
Rodriguez-Gil, Jorge L. (author)
Rosenberg, Lynn (author)
Ross, Eric (author)
Ruediger, Thomas (author)
Silva, Isabel dos Santos (author)
Sawyer, Elinor (author)
Schmidt, Marjanka K. (author)
Schulz-Wendtland, Ruediger (author)
Schumacher, Fredrick (author)
Severi, Gianluca (author)
Sheng, Xin (author)
Signorello, Lisa B. (author)
Sinn, Hans-Peter (author)
Stevens, Kristen N. (author)
Southey, Melissa C. (author)
Tapper, William J. (author)
Tomlinson, Ian (author)
Hogervorst, Frans B. L. (author)
Wauters, Els (author)
Weaver, JoEllen (author)
Wildiers, Hans (author)
Winqvist, Robert (author)
Van Den Berg, David (author)
Wan, Peggy (author)
Xia, Lucy Y. (author)
Yannoukakos, Drakoulis (author)
Zheng, Wei (author)
Ziegler, Regina G. (author)
Siddiq, Afshan (author)
Slager, Susan L. (author)
Stram, Daniel O. (author)
Easton, Douglas (author)
Kraft, Peter (author)
Henderson, Brian E. (author)
Couch, Fergus J. (author)
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 (creator_code:org_t)
2011-10-30
2011
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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By the author/editor
Haiman, Christop ...
Chen, Gary K.
Vachon, Celine M ...
Canzian, Federic ...
Dunning, Alison
Millikan, Robert ...
show more...
Wang, Xianshu
Ademuyiwa, Folus ...
Ahmed, Shahana
Ambrosone, Chris ...
Baglietto, Laura
Balleine, Rosema ...
Bandera, Elisa V ...
Beckmann, Matthi ...
Berg, Christine ...
Bernstein, Lesli ...
Blomqvist, Carl
Blot, William J.
Brauch, Hiltrud
Buring, Julie E.
Carey, Lisa A.
Carpenter, Jane ...
Chang-Claude, Je ...
Chanock, Stephen ...
Chasman, Daniel ...
Clarke, Christin ...
Cox, Angela
Cross, Simon S.
Deming, Sandra L ...
Diasio, Robert B ...
Dimopoulos, Atha ...
Driver, W. Ryan
Duennebier, Thom ...
Durcan, Lorraine
Eccles, Diana
Edlund, Christop ...
Ekici, Arif B.
Fasching, Peter ...
Feigelson, Heath ...
Flesch-Janys, Di ...
Fostira, Florent ...
Försti, Asta
Fountzilas, Geor ...
Gerty, Susan M.
Giles, Graham G.
Godwin, Andrew K ...
Goodfellow, Paul
Graham, Nikki
Greco, Dario
Hamann, Ute
Hankinson, Susan ...
Hartmann, Arndt
Hein, Rebecca
Heinz, Judith
Holbrook, Andrea
Hoover, Robert N ...
Hu, Jennifer J.
Hunter, David J.
Ingles, Sue A.
Irwanto, Astrid
Ivanovich, Jenni ...
John, Esther M.
Johnson, Nicola
Jukkola-Vuorinen ...
Kaaks, Rudolf
Ko, Yon-Dschun
Kolonel, Laurenc ...
Konstantopoulou, ...
Kosma, Veli-Matt ...
Kulkarni, Swati
Lambrechts, Diet ...
Lee, Adam M.
Le Marchand, Loi ...
Lesnick, Timothy
Liu, Jianjun
Lindstrom, Sara
Mannermaa, Arto
Margolin, Sara
Martin, Nicholas ...
Miron, Penelope
Montgomery, Gran ...
Nevanlinna, Heli
Nickels, Stephan
Nyante, Sarah
Olswold, Curtis
Palmer, Julie
Pathak, Harsh
Pectasides, Dimi ...
Perou, Charles M ...
Peto, Julian
Pharoah, Paul D. ...
Pooler, Loreall ...
Press, Michael F ...
Pylkas, Katri
Rebbeck, Timothy ...
Rodriguez-Gil, J ...
Rosenberg, Lynn
Ross, Eric
Ruediger, Thomas
Silva, Isabel do ...
Sawyer, Elinor
Schmidt, Marjank ...
Schulz-Wendtland ...
Schumacher, Fred ...
Severi, Gianluca
Sheng, Xin
Signorello, Lisa ...
Sinn, Hans-Peter
Stevens, Kristen ...
Southey, Melissa ...
Tapper, William ...
Tomlinson, Ian
Hogervorst, Fran ...
Wauters, Els
Weaver, JoEllen
Wildiers, Hans
Winqvist, Robert
Van Den Berg, Da ...
Wan, Peggy
Xia, Lucy Y.
Yannoukakos, Dra ...
Zheng, Wei
Ziegler, Regina ...
Siddiq, Afshan
Slager, Susan L.
Stram, Daniel O.
Easton, Douglas
Kraft, Peter
Henderson, Brian ...
Couch, Fergus J.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
Articles in the publication
Nature Genetics
By the university
Lund University
Karolinska Institutet

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