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Abbreviated Versus ...
Abbreviated Versus Standard Dual Antiplatelet Therapy Times After Percutaneous Coronary Intervention in Patients With High Bleeding Risk With Acute Coronary Syndrome: Insights From the SWEDEHEART Registry.
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- Håkansson, Anton (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Koul, Sasha (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Omerovic, Elmir, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Cardiology Sahlgrenska University Hospital, Gothenburg University Gothenburg Sweden, Sweden,Gothenburg Univ, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
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- Andersson, Jonas (författare)
- Umeå universitet,Kardiologi,Umeå Univ, Dept Cardiol, Umeå, Sweden.
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi
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- Agewall, Stefan (författare)
- Department of Clinical sciences, Danderyd Hospital Karolinska institutet Stockholm Sweden, Sweden,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
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- Mokhtari, Arash (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- van Der Pals, Jesper (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Wester, Axel (författare)
- Karolinska Institutet
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- Szummer, Karolina (författare)
- Department of Clinical sciences, Danderyd Hospital Karolinska institutet Stockholm Sweden, Sweden,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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- Erlinge, David (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Mohammad, Moman A (författare)
- Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden, Sweden Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden (creator_code:org_t)
- The American Heart Association, 2024
- 2024
- Engelska.
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Ingår i: Journal of the American Heart Association. - : The American Heart Association. - 2047-9980. ; 13:13
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Dual antiplatelet therapy (DAPT) reduces ischemic events but increases bleeding risk, especially in patients with high bleeding risk (HBR). This study aimed to compare outcomes of abbreviated versus standard DAPT strategies in patients with HBR with acute coronary syndrome undergoing percutaneous coronary intervention.Patients from the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-Based Bare in Heart Disease Evaluated According to Recommended Therapies) registry with at least 1 HBR criterion who underwent percutaneous coronary intervention for acute coronary syndrome were identified and included. Patients were divided into 2 groups based on their planned DAPT time at discharge: 12-month DAPT or an abbreviated DAPT strategy and matched according to their prescribed P2Y12 inhibitor at discharge. The primary outcome assessed was time to net adverse clinical events at 1year, which encompassed cardiac death, myocardial infarction, ischemic stroke, or clinically significant bleeding. Time to major adverse cardiovascular events and the individual components of net adverse clinical events were considered secondary end points. A total of 4583 patients were included in each group. The most frequently met HBR criteria was age older than 75years (65.6%) and Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy score ≥25 (44.6%) in the standard DAPT group and oral anticoagulant therapy (79.6%) and age 75years and older (55.2%) in the abbreviated DAPT group. There was no statistically significant difference in net adverse clinical events (12.9% versus 13.1%; hazard ratio [HR], 0.99 [95% CI, 0.88-1.11], P=0.83), major adverse cardiovascular events (8.6% versus 7.9%; HR, 1.08 [95% CI, 0.94-1.25]), or their components between groups. The results were consistent among all of the investigated subgroups.In patients with HBR undergoing percutaneous coronary intervention due to acute coronary syndrome, abbreviated DAPT was associated with comparable rates of net adverse clinical events and major adverse cardiovascular events to a DAPT duration of 12months.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Humans
- Acute Coronary Syndrome
- therapy
- mortality
- complications
- Percutaneous Coronary Intervention
- adverse effects
- Male
- Female
- Aged
- Registries
- Dual Anti-Platelet Therapy
- adverse effects
- methods
- Hemorrhage
- chemically induced
- epidemiology
- Platelet Aggregation Inhibitors
- adverse effects
- administration & dosage
- Middle Aged
- Time Factors
- Sweden
- epidemiology
- Risk Factors
- Risk Assessment
- Treatment Outcome
- Drug Administration Schedule
- Aged
- 80 and over
- Purinergic P2Y Receptor Antagonists
- adverse effects
- administration & dosage
- therapeutic use
- acute coronary syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Håkansson, Anton
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Koul, Sasha
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Omerovic, Elmir, ...
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Andersson, Jonas
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James, Stefan, 1 ...
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Agewall, Stefan
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Mokhtari, Arash
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van Der Pals, Je ...
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Wester, Axel
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Szummer, Karolin ...
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Jernberg, Tomas
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Erlinge, David
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Mohammad, Moman ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Kardiologi
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Journal of the A ...
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet