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Control computerize...
Control computerized tomography in neoadjuvant chemotherapy for muscle invasive urinary bladder cancer, has no value for treatment decisions and low correlation with nodal status
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- Tenninge, S. (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Mogos, H. (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Eriksson, E. (author)
- Umeå universitet,Diagnostisk radiologi,Umea Univ, Sweden
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- Netterling, H. (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Pelander, Sofia (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Johansson, Markus (author)
- Umeå universitet,Urologi och andrologi,Department of Urology, Sundsvall Hospital, Sundsvall, Sweden,Umea Univ, Sweden; Sundsvall Hosp, Sweden
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- Alamdari, F. (author)
- Vastmanland Hosp, Sweden
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- Huge, Ylva (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Abdul-Sattar Aljabery, Firas (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Svensson, Johan, 1978- (author)
- Umeå universitet,Statistik,Umea Univ, Sweden
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- Styrke, Johan (author)
- Umeå universitet,Urologi och andrologi,Department of Urology, Sundsvall Hospital, Sundsvall, Sweden,Umea Univ, Sweden; Sundsvall Hosp, Sweden
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- Sherif, Amir (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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(creator_code:org_t)
- 2021-09-30
- 2021
- English.
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In: Scandinavian journal of urology. - : Taylor & Francis. - 2168-1805 .- 2168-1813. ; 55:6, s. 455-460
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Abstract
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- BACKGROUND: Control computerized tomography (cCT) is routinely used in many cystectomy centres before the final treatment cycle in patients with muscle-invasive urinary bladder cancer (MIBC) undergoing neoadjuvant chemotherapy (NAC). This is for evaluating response or nonresponse to NAC treatment. In a real-world retrospective cohort, we intended to evaluate the frequency of changed individual treatment strategies following cCT and to investigate any discrepancies between cCT-results on nodal staging and final pN-stages.METHODS: We performed a retrospective data-based, multicenter study of 242 MIBC-patients, staged cT2N0M0-cT4aN0M0, having undergone NAC and radical cystectomy (RC) between 2008 and 2019 at four Swedish cystectomy centres. Statistical analysis was performed using IBM SPSS statistics 26.RESULTS: Overall, 139/242 patients were examined with cCT. Six patients were staged as progressive at cCT and 5/139 (3.6%) underwent a change of previously planned treatment strategy. 2/6 patients with suspected progression (33%) did not change strategy and underwent all preplanned NAC-cycles plus RC. Only 1/6 patients assigned as progressive at the cCT, showed progression in the postoperative pathology specimen. In total 133/139 patients were considered being without progress on cCT, yet 28/133 (21%) presented with nodal progression at postoperative pathology examinations. Only 1/29 patients with histopathologically verified nodal dissemination were detected with cCT, thus 28/29 (96.6%) with pN + were undetected. The sensitivity for cCT to predict pTNM was 17% CI [0%-64%] and the specificity was 78% CI [71%-86%].CONCLUSIONS: CCT prior to the final treatment cycle of NAC in MIBC, leads to a low percentage of treatment strategy changes and cCT cannot accurately predict pN-status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Computed X-ray tomography
- cystectomy
- interdisciplinary health team
- neoadjuvant therapy
- urinary bladder neoplasms
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tenninge, S.
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Mogos, H.
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Eriksson, E.
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Netterling, H.
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Pelander, Sofia
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Johansson, Marku ...
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Alamdari, F.
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Huge, Ylva
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Abdul-Sattar Alj ...
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Svensson, Johan, ...
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Styrke, Johan
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Sherif, Amir
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Scandinavian jou ...
- By the university
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Umeå University
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Linköping University