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Antiretroviral resi...
Antiretroviral resistance at virological failure in the NEAT 001/ANRS 143 trial: Raltegravir plus darunavir/ritonavir or tenofovir/emtricitabine plus darunavir/ritonavir as first-line ART
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- Lambert-Niclot, S. (author)
- Pitié-Salpêtrière University Hospital
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- George, E.C. (author)
- University College London
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- Pozniak, A. (author)
- Chelsea and Westminster Hospital
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- White, E. (author)
- University College London
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- Schwimmer, C. (author)
- National Institute for Health and Medical Research, France
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- Jessen, H. (author)
- Gemeinschaftspraxis Jessen-Stein
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- Johnson, M. (author)
- Royal Free Hospital
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- Dunn, D. (author)
- University College London
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- Perno, C.F. (author)
- University of Rome Tor Vergata
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- Clotet, B. (author)
- Hospital Universitari Germans Trias i Pujol
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- Plettenberg, A. (author)
- ifi – Institut für Interdisziplinäre Medizin
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- Blaxhult, A. (author)
- Karolinska Institutet,Stockholm South General Hospital
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- Palmisano, L. (author)
- Italian National Institute of Health (ISS)
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- Wittkop, L. (author)
- University of Bordeaux
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- Calvez, V. (author)
- Pitié-Salpêtrière University Hospital
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- Marcelin, A.G. (author)
- Pitié-Salpêtrière University Hospital
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- Raffi, F. (author)
- College of Professors of Infectious and Tropical Diseases
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Dedes, Nikos (author)
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Chěne, Geneviève (author)
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Allavena, Clotilde (author)
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Autran, Brigitte (author)
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Antinori, Andrea (author)
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Bucciardini, Raffaella (author)
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Vella, Stefano (author)
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Horban, Andrzej (author)
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Arribas, Jose (author)
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- Babiker, Abdel G. (author)
- University College London
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Boffito, Marta (author)
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Pillay, Deenan (author)
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Pozniak, Anton (author)
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Franquet, Xavier (author)
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Schwarze, Siegfried (author)
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- Grarup, Jesper (author)
- Copenhagen University Hospital
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- Fischer, Aurélie (author)
- University of Bordeaux
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- Richert, Laura (author)
- University of Bordeaux
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- Wallet, Cédrick (author)
- University of Bordeaux
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Raffi, François (author)
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- Diallo, Alpha (author)
- ANRS - France Recherche Nord & Sud Sida-HIV Hépatites virales
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Molina, Jean-Michel (author)
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- Saillard, Juliette (author)
- ANRS - France Recherche Nord & Sud Sida-HIV Hépatites virales
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- Moecklinghoff, Christiane (author)
- Janssen Pharmaceuticals, Germany
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Stellbrink, Hans-Jürgen (author)
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- Van Leeuwen, Remko (author)
- Academic Medical Center of University of Amsterdam (AMC)
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Gatell, Jose (author)
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Sandstrom, Eric (author)
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Flepp, Markus (author)
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- Ewings, Fiona (author)
- University College London
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- George, Elizabeth C. (author)
- University College London
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- Hudson, Fleur (author)
- University College London
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- Odermarsky, Michal (author)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Child and Family Health,Lund University Research Groups,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
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- 2015-12-24
- 2016
- English 7 s.
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press (OUP). - 1460-2091 .- 0305-7453. ; 71:4, s. 1056-1062
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https://academic.oup...
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Abstract
Subject headings
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- Objectives: To describe the pattern of drug resistance at virological failure in the NEAT001/ANRS143 trial (first-line treatment with ritonavir-boosted darunavir plus either tenofovir/emtricitabine or raltegravir). Methods: Genotypic testing was performed at baseline for reverse transcriptase (RT) and protease genes and for RT, protease and integrase (IN) genes for patients with a confirmed viral load (VL) >50 copies/mL or any single VL >500 copies/mL during or after week 32. Results: A resistance test was obtained for 110/805 (13.7%) randomized participants qualifying for resistance analysis (61/401 of participants in the raltegravir arm and 49/404 of participants in the tenofovir/emtricitabine arm). No resistance-associated mutation (RAM) was observed in the tenofovir/emtricitabine plus darunavir/ritonavir arm, and all further analyses were limited to the raltegravir plus darunavir arm. In this group, 15/55 (27.3%) participants had viruses with IN RAMs (12 N155H alone, 1 N155H + Q148R, 1 F121Y and 1 Y143C), 2/53 (3.8%) with nucleotide analogue RT inhibitor RAMs (K65R, M41L) and 1/57 (1.8%) with primary protease RAM (L76V). The frequency of IN mutations at failure was significantly associated with baseline VL: 7.1% for a VL of TREND = 0.007). Of note, 4/15 participants with IN RAM had a VL <200 copies/mL at time of testing. Conclusions: In the NEAT001/ANRS143 trial, there was no RAM at virological failure in the standard tenofovir/emtricitabine plus darunavir/ritonavir regimen, contrasting with a rate of 29.5% (mostly IN mutations) in the raltegravir plus darunavir/ritonavir NRTI-sparing regimen. The cumulative risk of IN RAM after 96 weeks of follow-up in participants initiating ART with raltegravir plus darunavir/ritonavir was 3.9%.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- clinical trial
- controlled clinical trial
- controlled study
- follow up
- gene frequency
- gene mutation
- genetic predisposition
- human
- major clinical study
- mutation
- randomized controlled trial
- virus load
- darunavir
- emtricitabine
- integrase
- nucleotide
- proteinase
- raltegravir
- ritonavir
- RNA directed DNA polymerase
- tenofovir
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lambert-Niclot, ...
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George, E.C.
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Pozniak, A.
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White, E.
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Schwimmer, C.
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Jessen, H.
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show more...
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Johnson, M.
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Dunn, D.
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Perno, C.F.
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Clotet, B.
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Plettenberg, A.
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Blaxhult, A.
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Palmisano, L.
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Wittkop, L.
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Calvez, V.
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Marcelin, A.G.
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Raffi, F.
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Dedes, Nikos
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Chěne, Geneviève
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Allavena, Clotil ...
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Autran, Brigitte
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Antinori, Andrea
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Bucciardini, Raf ...
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Vella, Stefano
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Horban, Andrzej
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Arribas, Jose
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Babiker, Abdel G ...
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Boffito, Marta
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Pillay, Deenan
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Pozniak, Anton
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Franquet, Xavier
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Schwarze, Siegfr ...
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Grarup, Jesper
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Fischer, Aurélie
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Richert, Laura
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Wallet, Cédrick
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Raffi, François
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Diallo, Alpha
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Molina, Jean-Mic ...
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Saillard, Juliet ...
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Moecklinghoff, C ...
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Stellbrink, Hans ...
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Van Leeuwen, Rem ...
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Gatell, Jose
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Sandstrom, Eric
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Flepp, Markus
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Ewings, Fiona
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George, Elizabet ...
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Hudson, Fleur
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Odermarsky, Mich ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Antim ...
- By the university
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Lund University
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Karolinska Institutet