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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Soranzo, Nicole (author)
Spector, Tim D. (author)
Mangino, Massimo (author)
show more...
Kuehnel, Brigitte (author)
Rendon, Augusto (author)
Teumer, Alexander (author)
Willenborg, Christina (author)
Wright, Benjamin (author)
Chen, Li (author)
Li, Mingyao (author)
Salo, Perttu (author)
Voight, Benjamin F. (author)
Burns, Philippa (author)
Laskowski, Roman A. (author)
Xue, Yali (author)
Menzel, Stephan (author)
Altshuler, David (author)
Bradley, John R. (author)
Bumpstead, Suzannah (author)
Burnett, Mary-Susan (author)
Devaney, Joseph (author)
Doering, Angela (author)
Elosua, Roberto (author)
Epstein, Stephen E. (author)
Erber, Wendy (author)
Falchi, Mario (author)
Garner, Stephen F. (author)
Ghori, Mohammed J. R. (author)
Goodall, Alison H. (author)
Gwilliam, Rhian (author)
Hakonarson, Hakon H. (author)
Hall, Alistair S. (author)
Hammond, Naomi (author)
Hengstenberg, Christian (author)
Illig, Thomas (author)
Koenig, Inke R. (author)
Knouff, Christopher W. (author)
McPherson, Ruth (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Mooser, Vincent (author)
Nauck, Matthias (author)
Nieminen, Markku S. (author)
O'Donnell, Christopher J. (author)
Peltonen, Leena (author)
Potter, Simon C. (author)
Prokisch, Holger (author)
Rader, Daniel J. (author)
Rice, Catherine M. (author)
Roberts, Robert (author)
Salomaa, Veikko (author)
Sambrook, Jennifer (author)
Schreiber, Stefan (author)
Schunkert, Heribert (author)
Schwartz, Stephen M. (author)
Serbanovic-Canic, Jovana (author)
Sinisalo, Juha (author)
Siscovick, David S. (author)
Stark, Klaus (author)
Surakka, Ida (author)
Stephens, Jonathan (author)
Thompson, John R. (author)
Voelker, Uwe (author)
Voelzke, Henry (author)
Watkins, Nicholas A. (author)
Wells, George A. (author)
Wichmann, H-Erich (author)
Van Heel, David A. (author)
Tyler-Smith, Chris (author)
Thein, Swee Lay (author)
Kathiresan, Sekar (author)
Perola, Markus (author)
Reilly, Muredach P. (author)
Stewart, Alexandre F. R. (author)
Erdmann, Jeanette (author)
Samani, Nilesh J. (author)
Meisinger, Christa (author)
Greinacher, Andreas (author)
Deloukas, Panos (author)
Ouwehand, Willem H. (author)
Gieger, Christian (author)
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 (creator_code:org_t)
2009-10-11
2009
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

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By the author/editor
Soranzo, Nicole
Spector, Tim D.
Mangino, Massimo
Kuehnel, Brigitt ...
Rendon, Augusto
Teumer, Alexande ...
show more...
Willenborg, Chri ...
Wright, Benjamin
Chen, Li
Li, Mingyao
Salo, Perttu
Voight, Benjamin ...
Burns, Philippa
Laskowski, Roman ...
Xue, Yali
Menzel, Stephan
Altshuler, David
Bradley, John R.
Bumpstead, Suzan ...
Burnett, Mary-Su ...
Devaney, Joseph
Doering, Angela
Elosua, Roberto
Epstein, Stephen ...
Erber, Wendy
Falchi, Mario
Garner, Stephen ...
Ghori, Mohammed ...
Goodall, Alison ...
Gwilliam, Rhian
Hakonarson, Hako ...
Hall, Alistair S ...
Hammond, Naomi
Hengstenberg, Ch ...
Illig, Thomas
Koenig, Inke R.
Knouff, Christop ...
McPherson, Ruth
Melander, Olle
Mooser, Vincent
Nauck, Matthias
Nieminen, Markku ...
O'Donnell, Chris ...
Peltonen, Leena
Potter, Simon C.
Prokisch, Holger
Rader, Daniel J.
Rice, Catherine ...
Roberts, Robert
Salomaa, Veikko
Sambrook, Jennif ...
Schreiber, Stefa ...
Schunkert, Herib ...
Schwartz, Stephe ...
Serbanovic-Canic ...
Sinisalo, Juha
Siscovick, David ...
Stark, Klaus
Surakka, Ida
Stephens, Jonath ...
Thompson, John R ...
Voelker, Uwe
Voelzke, Henry
Watkins, Nichola ...
Wells, George A.
Wichmann, H-Eric ...
Van Heel, David ...
Tyler-Smith, Chr ...
Thein, Swee Lay
Kathiresan, Seka ...
Perola, Markus
Reilly, Muredach ...
Stewart, Alexand ...
Erdmann, Jeanett ...
Samani, Nilesh J ...
Meisinger, Chris ...
Greinacher, Andr ...
Deloukas, Panos
Ouwehand, Willem ...
Gieger, Christia ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Lund University

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