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Abnormalities in ky...
Abnormalities in kynurenine pathway metabolism in treatment-resistant depression and suicidality : a systematic review
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- Serafini, Gianluca (författare)
- University of Genoa
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- Adavastro, Giulia (författare)
- University of Genoa
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- Canepa, Giovanna (författare)
- University of Genoa
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- Capobianco, Laura (författare)
- University of Genoa
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- Conigliaro, Claudia (författare)
- University of Genoa
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- Pittaluga, Federica (författare)
- University of Genoa
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- Belvederi Murri, Martino (författare)
- University of Genoa
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- Valchera, Alessandro (författare)
- Villa San Giuseppe Hospital
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- De Berardis, Domenico (författare)
- Villa San Giuseppe Hospital
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- Pompili, Maurizio (författare)
- Sapienza University of Rome
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- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for clinical suicide research,Lund University Research Groups
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- Brundin, Lena (författare)
- Van Andel Research Institute
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- Amore, Mario (författare)
- University of Genoa
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(creator_code:org_t)
- Bentham Science Publishers Ltd. 2017
- 2017
- Engelska.
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Ingår i: CNS and Neurological Disorders - Drug Targets. - : Bentham Science Publishers Ltd.. - 1871-5273. ; 16:4, s. 440-453
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neurobiological determinants underlying these complex conditions, their pathophysiology still remains unclear. Compared to non-suicidal subjects, higher mean concentrations of inflammatory mediators have been found in both the periphery and brain of individuals at risk for suicide. Several lines of evidence suggest that neuroinflammation is accompanied by a dysregulation of the kynurenine pathway (KP) in both TRD and suicidal individuals, resulting in an imbalance of neuroactive metabolites. In particular, neuroinflammation may trigger an increased production of the N-Methyl-D-aspartate (NMDA) receptor agonist quinolinic acid and a concomitant reduction of neuroprotective metabolites, potentially causing downstream effects in glutamatergic systems resulting in depressive symptoms and suicidal behavior. This systematic review of the current literature is mainly aimed at summarizing the most important evidence pertaining to KP metabolism abnormalities in TRD and suicidal behavior. Targeting the KP enzymes may provide innovative approaches in the management of both TRD and suicidality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Kynurenine pathway
- quinolinic acid
- tryptophan
- treatment-resistant depression
- suicidal behavior
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Serafini, Gianlu ...
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Adavastro, Giuli ...
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Canepa, Giovanna
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Capobianco, Laur ...
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Conigliaro, Clau ...
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Pittaluga, Feder ...
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Belvederi Murri, ...
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Valchera, Alessa ...
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De Berardis, Dom ...
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Pompili, Maurizi ...
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Lindqvist, Danie ...
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Brundin, Lena
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Amore, Mario
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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CNS and Neurolog ...
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