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Sökning: onr:"swepub:oai:DiVA.org:uu-389830" > Data-driven adult a...

Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later

Boudier, Anne (författare)
Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France
Chanoine, Sebastien (författare)
Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France;Univ Grenoble Alpes, Fac Pharm, Grenoble, France;CHU Grenoble Alpes, Pole Pharm, Grenoble, France
Accordini, Simone (författare)
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
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Anto, Josep M. (författare)
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
Basagana, Xavier (författare)
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
Bousquet, Jean (författare)
INSERM, Aging & Chron Dis U1168, Epidemiol & Publ Hlth Approaches, Villejuif, France
Demoly, Pascal (författare)
CHU Montpellier, Dept Pneumol, Montpellier, France
Garcia-Aymerich, Judith (författare)
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
Gormand, Frederic (författare)
CHU Lyon, Dept Pneumol, Lyon, France
Heinrich, Joachim (författare)
Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Comprehens Pneumol Ctr Munich, Univ Hosp,German Ctr Lung Res, Munich, Germany
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Kunzli, Nino (författare)
Univ Basel, Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Matran, Regis (författare)
Univ Lille, CHU, Lille, France
Pison, Christophe (författare)
Univ Grenoble Alpes, CHU Grenoble, Clin Univ Pneumol, Pole Thorax & Vaisseaux,INSERM,U1055, Grenoble, France
Raherison, Chantal (författare)
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team EPICENE, INSERM,UMR 1219, Bordeaux, France
Sunyer, Jordi (författare)
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
Varraso, Raphaelle (författare)
INSERM, Aging & Chron Dis U1168, Epidemiol & Publ Hlth Approaches, Villejuif, France
Jarvis, Deborah (författare)
Imperial Coll, Natl Heart & Lung Inst, London, England
Leynaert, Benedicte (författare)
Univ Paris Diderot, Team Epidemiol, INSERM, Unit 1152, Paris, France
Pin, Isabelle (författare)
Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France;CHU Grenoble, Dept Pediat, Grenoble, France
Siroux, Valerie (författare)
Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France
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 (creator_code:org_t)
2019-01-15
2019
Engelska.
Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 74:5, s. 953-963
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BackgroundResearch based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long-term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20years earlier. MethodsThe study relied on two cohorts of adults with asthma with 20-year follow-up, ECRHS (European Community Respiratory Health Survey) and EGEA (Epidemiological study on Genetics and Environment of Asthma). Regression models were used to compare asthma characteristics (current asthma, asthma exacerbations, asthma control, quality of life, and FEV1) at follow-up and the course of FEV(1)between sevencluster-based asthma phenotypes identified20years earlier. ResultsThe analysis included 1325 adults with ever asthma. For each asthma characteristic assessed at follow-up, the risk for adverse outcomes differed significantly between the seven asthma clusters identified at baseline. As compared with the mildest asthma phenotype, ORs (95% CI) for asthma exacerbations varied from 0.9 (0.4 to 2.0) to 4.0 (2.0 to 7.8) and the regression estimates (95% CI) for FEV1% predicted varied from 0.6 (-3.5 to 4.6) to -9.9 (-14.2 to -5.5) between clusters. Change in FEV1 over time did not differ significantly across clusters. ConclusionOur findings show that the long-term risk for poor asthma outcomes differed between comprehensive adult asthma phenotypes identified 20years earlier, and suggest a strong tracking of asthma activity and impaired lung function over time.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

asthma
clustering
follow-up
lung function
phenotypes

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