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Atopy Modifies the ...
Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma
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- Marcon, Alessandro (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
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- Marchetti, Pierpaolo (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
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- Anto, Josep M. (författare)
- Inst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
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- Cazzoletti, Lucia (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
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- Cerveri, Isa (författare)
- Univ Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy
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- Corsico, Angelo (författare)
- Univ Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy
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- Ferreira, Diogenes Seraphim (författare)
- Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia;Univ Fed Parana, Complexo Hosp Clin, Alergia & Imunol, Curitiba, Parana, Brazil
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- Garcia-Aymerich, Judith (författare)
- Inst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
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- Gislason, David (författare)
- Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland
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- Heinrich, Joachim (författare)
- Maximilians Univ, Univ Hosp Ludwig, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany;German Ctr Lung Res, Comprehens Pneumol Ctr Munich, Munich, Germany
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- Jogi, Rain (författare)
- Univ Tartu, Dept Pneumol, Tartu, Estonia
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- Johannessen, Ane (författare)
- Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway
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- Leynaert, Benedicte (författare)
- VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Inserm U1168, Villejuif, France;Univ Versailles St Quentin Yvelines, UMR S 1168, UVSQ, St Quentin En Yvelines, France
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi
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- Pin, Isabelle (författare)
- Ctr Hosp Univ Grenoble Alpes, Pediat, Grenoble, France;INSERM, Inst Adv Biosci, Grenoble, France;Univ Grenoble Alpes, Grenoble, France
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- Probst-Hensch, Nicole (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland;Univ Basel, Basel, Switzerland
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- Weyler, Joost (författare)
- Univ Antwerp, StatUA Stat Ctr, Epidemiol & Social Med, Antwerp, Belgium
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Jarvis, Deborah (författare)
- Imperial Coll London, Natl Heart & Lung Inst, London, England;Imperial Coll London, MRC, PHE, Ctr Environm & Hlth, London, England
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- Accordini, Simone (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
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(creator_code:org_t)
- ELSEVIER, 2020
- 2020
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology. - : ELSEVIER. - 2213-2198 .- 2213-2201. ; 8:3, s. 980-
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Abstract
Ämnesord
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- BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. OBJECTIVE: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. METHODS: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). RESULTS: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (P-interaction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. CONCLUSIONS: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Allergic sensitization
- Asthma
- Atopy
- Cohort study
- Epidemiology
- IgE
- Inhaled corticosteroids
- Lung function decline
- Precision medicine
- Response to corticosteroids
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Marcon, Alessand ...
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Marchetti, Pierp ...
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Anto, Josep M.
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Cazzoletti, Luci ...
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Cerveri, Isa
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Corsico, Angelo
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visa fler...
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Ferreira, Diogen ...
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Garcia-Aymerich, ...
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Gislason, David
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Heinrich, Joachi ...
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Jogi, Rain
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Johannessen, Ane
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Leynaert, Benedi ...
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Malinovschi, And ...
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Pin, Isabelle
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Probst-Hensch, N ...
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Weyler, Joost
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Janson, Christer
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Jarvis, Deborah
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Accordini, Simon ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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Journal of Aller ...
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Uppsala universitet