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A compendium answering 150 questions on COVID-19 and SARS-CoV-2

Riggioni, Carmen (author)
Hospital Sant Joan de Déu Barcelona
Comberiati, Pasquale (author)
University of Pisa,I.M. Sechenov First Moscow State Medical University
Giovannini, Mattia (author)
Meyer Children's Hospital
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Agache, Ioana (author)
Transylvania University Brasov
Akdis, Mübeccel (author)
University of Zurich
Alves-Correia, Magna (author)
University of Porto,Centro Hospitalar Universitário Porto
Antó, Josep M. (author)
Hospital del Mar Medical Research Institute,Centre for Research in Environmental Epidemiology,CIBER Epidemiology and Public Health (CIBERESP),Pompeu Fabra University
Arcolaci, Alessandra (author)
University of Verona
Azkur, Ahmet Kursat (author)
Azkur, Dilek (author)
Beken, Burcin (author)
Boccabella, Cristina (author)
Policlinico Universitario Agostino Gemelli
Bousquet, Jean (author)
Berlin Institute of Health (BIH),Charité - University Medicine Berlin
Breiteneder, Heimo (author)
Carvalho, Daniela (author)
NOVA University Lisbon
De las Vecillas, Leticia (author)
University of Cantabria
Diamant, Zuzana (author)
Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Charles University in Prague,University Medical Center Groningen
Eguiluz-Gracia, Ibon (author)
Hospital Regional de Málaga
Eiwegger, Thomas (author)
Hospital for Sick Children, Toronto,University of Toronto
Eyerich, Stefanie (author)
Helmholtz Zentrum München
Fokkens, Wytske (author)
Academic Medical Center of University of Amsterdam (AMC)
Gao, Ya dong (author)
Hannachi, Farah (author)
Johnston, Sebastian L. (author)
Imperial College London
Jutel, Marek (author)
Wroclaw University
Karavelia, Aspasia (author)
Klimek, Ludger (author)
Center for Rhinology and Allergology
Moya, Beatriz (author)
12 de Octubre University Hospital
Nadeau, Kari C. (author)
Stanford University
O'Hehir, Robyn (author)
Monash University
O'Mahony, Liam (author)
Pfaar, Oliver (author)
University Hospital Giessen and Marburg
Sanak, Marek (author)
Jagiellonian University
Schwarze, Jürgen (author)
University of Edinburgh
Sokolowska, Milena (author)
University of Zurich,Christine Kühne Center for Allergy Research and Education (CK-CARE)
Torres, María J. (author)
Hospital Regional de Málaga
van de Veen, Willem (author)
Christine Kühne Center for Allergy Research and Education (CK-CARE),University of Zurich
van Zelm, Menno C. (author)
Monash University
Wang, De Yun (author)
National University of Singapore
Zhang, Luo (author)
Beijing Tongren Hospital
Jiménez-Saiz, Rodrigo (author)
CSIC National Center for Biotechnology (CNB),Francisco de Vitoria University
Akdis, Cezmi A. (author)
University of Zurich
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 (creator_code:org_t)
2020-07-20
2020
English 39 s.
In: Allergy: European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538. ; 75:10, s. 2503-2541
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19–related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

allergy
coronavirus disease 2019
COVID-19
SARS-CoV-2
severe acute respiratory syndrome–related coronavirus 2

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