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Rivaroxaban for sec...
Rivaroxaban for secondary stroke prevention in patients with embolic strokes of undetermined source : Design of the NAVIGATE ESUS randomized trial
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- Hart, Robert G. (författare)
- McMaster University
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- Sharma, Mukul (författare)
- McMaster University
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- Mundl, Hardi (författare)
- Bayer Pharma AG
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- Shoamanesh, Ashkan (författare)
- McMaster University
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- Kasner, Scott E. (författare)
- University of Pennsylvania
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- Berkowitz, Scott D. (författare)
- Bayer Corporation, USA
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- Pare, Guillaume (författare)
- McMaster University
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- Kirsch, Bodo (författare)
- Bayer Pharma AG
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- Pogue, Janice (författare)
- McMaster University
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- Pater, Calin (författare)
- Bayer Pharma AG
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- Peters, Gary (författare)
- Janssen Pharmaceuticals, US
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- Davalos, Antoni (författare)
- Hospital Universitari Germans Trias i Pujol
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Lang, Wilfried (författare)
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- Wang, Yilong (författare)
- Beijing Tiantan Hospital
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- Cunha, Luis (författare)
- University Hospital of Coimbra
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- Eckstein, Jens (författare)
- University Hospital Basel
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- Tatlisumak, Turgut (författare)
- Helsinki University Central Hospital
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- Shamalov, Nikolay (författare)
- Pirogov Russian National Research Medical University (RNRMU)
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- Mikulik, Robert (författare)
- University Hospital Brno
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- Lavados, Pablo (författare)
- Universidad del Desarrollo
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- Hankey, Graeme J. (författare)
- University of Western Australia, Crawley
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- Czlonkowska, Anna (författare)
- Medical University of Warsaw
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- Toni, Danilo (författare)
- Sapienza University of Rome
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- Ameriso, Sebastian F. (författare)
- Fundacion Para La Lucha Contra Las Enfermedades Neurologicas de La Infancia (FLENI)
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- Gagliardi, Rubens J. (författare)
- Irmandade da Santa Casa de Misericordia de Sao Paulo
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- Amarenco, Pierre (författare)
- Hopital Bichat-Claude-Bernard AP-HP
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- Bereczki, Daniel (författare)
- Semmelweis University
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- Uchiyama, Shinichiro (författare)
- Sanno Hospital
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- Lindgren, Arne (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Endres, Matthias (författare)
- Charité - University Medicine Berlin
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- Brouns, Raf (författare)
- Universitair Ziekenhuis Brussel
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- Yoon, Byung Woo (författare)
- Seoul National University Hospital
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- Ntaios, George (författare)
- University of Thessaly
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- Veltkamp, Roland (författare)
- Imperial College London
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- Muir, Keith W. (författare)
- University of Glasgow
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- Ozturk, Serefnur (författare)
- Selcuk University
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- Arauz, Antonio (författare)
- Instituto Nacional de Neurología y Neurocirugía
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- Bornstein, Natan (författare)
- Tel Aviv Sourasky Medical Center – Ichilov Hospital
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Bryer, Alan (författare)
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- O’Donnell, Martin J. (författare)
- National University of Ireland Galway
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Weitz, Jeffrey (författare)
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- Peacock, Frank (författare)
- Baylor College of Medicine
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- Themeles, Ellison (författare)
- Population Health Research Institute, Ontario
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- Connolly, Stuart J. (författare)
- McMaster University
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(creator_code:org_t)
- 2016-08-11
- 2016
- Engelska 9 s.
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 1:3, s. 146-154
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.sag...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Embolic strokes of undetermined source comprise up to 20% of ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source international trial will compare the efficacy and safety of rivaroxaban, an oral factor Xa inhibitor, versus aspirin for secondary prevention in patients with recent embolic strokes of undetermined source. Main hypothesis: In patients with recent embolic strokes of undetermined source, rivaroxaban 15 mg once daily will reduce the risk of recurrent stroke (both ischemic and hemorrhagic) and systemic embolism (primary efficacy outcome) compared with aspirin 100 mg once daily. Design: Double-blind, randomized trial in patients with embolic strokes of undetermined source, defined as nonlacunar cryptogenic ischemic stroke, enrolled between seven days and six months from the qualifying stroke. The planned sample size of 7000 participants will be recruited from approximately 480 sites in 31 countries between 2014 and 2017 and followed for a mean of about two years until at least 450 primary efficacy outcome events have occurred. The primary safety outcome is major bleeding. Two substudies assess (1) the relative effect of treatments on MRI-determined covert brain infarcts and (2) the biological underpinnings of embolic strokes of undetermined source using genomic and biomarker approaches. Summary: The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source trial is evaluating the benefits and risks of rivaroxaban for secondary stroke prevention in embolic strokes of undetermined source patients. Main results are anticipated in 2018.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- aspirin
- cerebral embolism
- cryptogenic stroke
- embolic stroke of undetermined source
- randomized trial
- rivaroxaban
- Stroke
- stroke prevention
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Hart, Robert G.
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Sharma, Mukul
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Mundl, Hardi
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Shoamanesh, Ashk ...
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Kasner, Scott E.
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Berkowitz, Scott ...
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visa fler...
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Pare, Guillaume
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Kirsch, Bodo
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Pogue, Janice
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Pater, Calin
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Peters, Gary
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Davalos, Antoni
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Lang, Wilfried
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Wang, Yilong
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Cunha, Luis
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Eckstein, Jens
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Tatlisumak, Turg ...
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Shamalov, Nikola ...
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Mikulik, Robert
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Lavados, Pablo
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Hankey, Graeme J ...
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Czlonkowska, Ann ...
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Toni, Danilo
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Ameriso, Sebasti ...
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Gagliardi, Ruben ...
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Amarenco, Pierre
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Bereczki, Daniel
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Uchiyama, Shinic ...
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Lindgren, Arne
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Endres, Matthias
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Brouns, Raf
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Yoon, Byung Woo
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Ntaios, George
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Veltkamp, Roland
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Muir, Keith W.
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Ozturk, Serefnur
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Arauz, Antonio
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Bornstein, Natan
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Bryer, Alan
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O’Donnell, Marti ...
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Weitz, Jeffrey
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Peacock, Frank
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Themeles, Elliso ...
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Connolly, Stuart ...
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