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Pembrolizumab in re...
Pembrolizumab in relapsed or refractory Hodgkin lymphoma : 2-year follow-up of KEYNOTE-087
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- Chen, Robert (author)
- City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplant, 1500 E Duarte Rd, Duarte, CA 91010 USA
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- Zinzani, Pier Luigi (author)
- Univ Bologna, Inst Hematol Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy
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- Lee, Hun Ju (author)
- Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA
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- Armand, Philippe (author)
- Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
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- Johnson, Nathalie A. (author)
- Jewish Gen Hosp, Dept Hematol, Montreal, PQ, Canada
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- Brice, Pauline (author)
- Hop St Louis, Dept Hematol Oncol, Paris, France
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- Radford, John (author)
- Univ Manchester, Div Canc Sci, Manchester, Lancs, England;Christie NHS Fdn Trust, Manchester, Lancs, England
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- Ribrag, Vincent (author)
- Inst Gustave Roussy, Dept Drug Dev & Hematol, Villejuif, France
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- Molin, Daniel, 1969- (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Vassilakopoulos, Theodoros P. (author)
- Gen Hosp Athens, Dept Hematol & Bone Marrow Transplantat, Athens, Greece
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- Tomita, Akihiro (author)
- Fujita Hlth Univ, Sch Med, Dept Hematol, Toyoake, Aichi, Japan
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- von Tresckow, Bastian (author)
- Univ Cologne, Dept Internal Med, Cologne, Germany;Univ Hosp Cologne, Cologne, Germany
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- Shipp, Margaret A. (author)
- Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
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- Lin, Jianxin (author)
- Merck & Co Inc, Med Oncol, Kenilworth, NJ USA
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- Kim, Eunhee (author)
- Merck & Co Inc, Med Oncol, Kenilworth, NJ USA
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- Nahar, Akash (author)
- Merck & Co Inc, Med Oncol, Kenilworth, NJ USA
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- Balakumaran, Arun (author)
- Merck & Co Inc, Med Oncol, Kenilworth, NJ USA
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- Moskowitz, Craig H. (author)
- Univ Miami, Dept Med, Sylvester Comprehens Canc Ctr, Miami, FL USA
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(creator_code:org_t)
- 2019-08-13
- 2019
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 134:14, s. 1144-1153
- Related links:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Programmed death-1 inhibitors are approved for patients with relapsed or refractory classic Hodgkin lymphoma (RRcHL). We present the 2-year follow-up of the phase 2 KEYNOTE-087 study of pembrolizumab in 210 patients, based on HL progression after autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV; cohort 1); salvage chemotherapy and BV, with ineligibility for SCT owing to chemorefractory disease (cohort 2); and progression after SCT without BV (cohort 3). With a median follow-up of 27.6 months, the objective response rate (ORR) by blinded independent central review was 71.9% (95% CI, 65.3-77.9), the complete response rate (CRR) was 27.6%, and the partial response (PR) rate was 44.3%. Median duration of response was 16.5months (range, 0.0+ to 27.0+ [+, no progressive disease at last assessment]) in all patients, 22.1months in cohort 1, 11.1 months in cohort 2, and 24.4 months in cohort 3. Median progression-free survival was not reached in all patients with CR: 13.8 months (95% CI, 12.0-22.1) for patients with PR and 10.9 months (95% CI, 5.6-11.1) for patients with stable disease. Median overall survival was not reached in all patients or in any cohort. Treatment-related adverse events (TRAEs) of any grade occurred in 153 (72.9%) patients; grades 3 and 4 occurred in 25 (12.0%) patients; none resulted in death. Results confirmed effective antitumor activity, durability of response, and manageable safety of pembrolizumab monotherapy in RRcHL, regardless of prior treatment and including chemoresistant cHL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Chen, Robert
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Zinzani, Pier Lu ...
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Lee, Hun Ju
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Armand, Philippe
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Johnson, Nathali ...
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Brice, Pauline
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Radford, John
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Ribrag, Vincent
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Molin, Daniel, 1 ...
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Vassilakopoulos, ...
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Tomita, Akihiro
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von Tresckow, Ba ...
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Shipp, Margaret ...
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Lin, Jianxin
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Kim, Eunhee
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Nahar, Akash
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Balakumaran, Aru ...
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Moskowitz, Craig ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Uppsala University