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Soluble IL-1 recept...
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
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- Orrem, Hilde L. (author)
- Oslo Univ Hosp, Norway;Univ Oslo, Norway
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- Shetelig, Christian (author)
- Univ Oslo, Norway;Oslo Univ Hosp Ulleval, Norway
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- Ueland, Thor (author)
- Univ Oslo, Norway;Oslo Univ Hosp, Norway;Univ Tromso, Norway
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- Limalanathan, Shanmuganathan (author)
- Oslo Univ Hosp Ulleval, Norway;Feiring Heart Clin, Norway
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- Nilsson, Per H., 1980- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Univ Oslo, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
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- Husebye, Trygve (author)
- Oslo Univ Hosp Ulleval, Norway;Univ Oslo, Norway
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- Aukrust, Pal (author)
- Univ Oslo, Norway;Oslo Univ Hosp, Norway
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- Seljeflot, Ingebjorg (author)
- Univ Oslo, Norway;Oslo Univ Hosp Ulleval, Norway
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- Hoffmann, Pavel (author)
- Univ Oslo, Norway;Oslo Univ Hosp Ulleval, Norway
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- Eritsland, Jan (author)
- Oslo Univ Hosp Ulleval, Norway
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- Mollnes, Tom E. (author)
- Oslo Univ Hosp, Norway;Univ Tromso, Norway;Univ Oslo, Norway;Nordland Hosp, Norway;Norwegian Univ Sci, Norway
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- Andersen, Geir Oystein (author)
- Oslo Univ Hosp Ulleval, Norway;Univ Oslo, Norway
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- Yndestad, Arne (author)
- Univ Oslo, Norway;Oslo Univ Hosp, Norway
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 268, s. 187-192
- Related links:
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https://munin.uit.no...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1 alpha and IL-1 beta are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling. Methods: Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n=65). Results: IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates. Conclusion: Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI. (C 18 Elsevier B.V. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Inflammation
- Cytokine
- Interleukin-1
- Acute coronary syndromes
- Myocardial infarction
- Ventricular remodelling
- Biomedical Sciences
- Biomedicinsk vetenskap
- Biokemi
- Biochemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Orrem, Hilde L.
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Shetelig, Christ ...
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Ueland, Thor
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Limalanathan, Sh ...
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Nilsson, Per H., ...
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Husebye, Trygve
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Aukrust, Pal
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Seljeflot, Ingeb ...
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Hoffmann, Pavel
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Eritsland, Jan
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Mollnes, Tom E.
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Andersen, Geir O ...
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Yndestad, Arne
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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International Jo ...
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Linnaeus University