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Circulating free in...
Circulating free insulin-like growth factor-I and prostate cancer : a case-control study nested in the European prospective investigation into cancer and nutrition
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- Cheng, Tuck Seng (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom
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- Noor, Urwah (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom
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- Watts, Eleanor (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
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- Pollak, Michael (författare)
- Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada
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- Wang, Ye (författare)
- Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada
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- McKay, James (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Atkins, Joshua (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Masala, Giovanna (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Sánchez, Maria-Jose (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Agudo, Antonio (författare)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
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- Castilla, Jesús (författare)
- Instituto de Salud Pública de Navarra - IdiSNA, Pamplona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Aune, Dagfinn (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevå, Oslo, Norway
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- Colorado-Yohar, Sandra M. (författare)
- Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Manfredi, Luca (författare)
- Centre for Biostatistics, Epidemiology, Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC- WHO), Lyon, France
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- Pala, Valeria (författare)
- Epidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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- Josefsson, Andreas, 1979- (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Urologi och andrologi,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Key, Timothy J. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom
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- Smith-Byrne, Karl (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom
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(creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavailable form), and few studies have investigated the association of circulating free IGF-I with prostate cancer risk.METHODS: We analyzed data from 767 prostate cancer cases and 767 matched controls nested within the European Prospective Investigation into Cancer and Nutrition cohort, with an average of 14-years (interquartile range = 2.9) follow-up. Matching variables were study center, length of follow-up, age, and time of day and fasting duration at blood collection. Circulating free IGF-I concentration was measured in serum samples collected at recruitment visit (mean age 55 years old; standard deviation = 7.1) using an enzyme-linked immunosorbent assay (ELISA). Conditional logistic regressions were performed to examine the associations of free IGF-I with risk of prostate cancer overall and subdivided by time to diagnosis (≤ 14 and > 14 years), and tumor characteristics.RESULTS: Circulating free IGF-I concentrations (in fourths and as a continuous variable) were not associated with prostate cancer risk overall (odds ratio [OR] = 1.00 per 0.1 nmol/L increment, 95% CI: 0.99, 1.02) or by time to diagnosis, or with prostate cancer subtypes, including tumor stage and histological grade.CONCLUSIONS: Estimated circulating free IGF-I was not associated with prostate cancer risk. Further research may consider other assay methods that estimate bioavailable IGF-I to provide more insight into the well-substantiated association between circulating total IGF-I and subsequent prostate cancer risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Aggressiveness
- Free IGF-1
- Histological grade
- Prostate cancer
- Tumor stage
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Cheng, Tuck Seng
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Noor, Urwah
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Watts, Eleanor
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Pollak, Michael
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Wang, Ye
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McKay, James
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Atkins, Joshua
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Masala, Giovanna
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Sánchez, Maria-J ...
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Agudo, Antonio
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Castilla, Jesús
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Aune, Dagfinn
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Colorado-Yohar, ...
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Manfredi, Luca
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Gunter, Marc J.
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Pala, Valeria
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Josefsson, Andre ...
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Key, Timothy J.
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Smith-Byrne, Kar ...
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Travis, Ruth C.
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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BMC Cancer
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Umeå universitet