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Relationship Between Early-Pregnancy Glycemia and Adverse Outcomes : Findings From the TOBOGM Study
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- Sweeting, Arianne (författare)
- Department of Endocrinology, Royal Prince Alfred Hospital and University of Sydney, Sydney, New South Wales, Australia
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- Enticott, Joanne (författare)
- Monash University, Melbourne, Victoria, Australia
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- Immanuel, Jincy (författare)
- Western Sydney University, Campbelltown, New South Wales, Australia
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- Hague, William M. (författare)
- Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
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- Teede, Helena (författare)
- Monash University, Melbourne, Victoria, Australia
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- Nolan, Christopher J. (författare)
- Canberra Hospital and Australian National University, Canberra, Australia Capital Territory, Australia
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- Peek, Michael J. (författare)
- Australian National University, Canberra, Australia Capital Territory, Australia
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- Flack, Jeff R. (författare)
- Bankstown-Lidcombe Hospital, Sydney, New South Wales, Australia
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- McLean, Mark (författare)
- Blacktown Hospital, Blacktown, New South Wales, Australia
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- Wong, Vincent W. (författare)
- Liverpool Hospital and University of New South Wales, Sydney, New South Wales, Australia
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- Hibbert, Emily J. (författare)
- Nepean Clinical School, University of Sydney, and Nepean Hospital, Sydney, New South Wales, Australia
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- Kautzky-Willer, Alexandra (författare)
- Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
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- Harreiter, Jürgen (författare)
- Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Department of Medicine, Landesklinikum Scheibbs, Scheibbs, Austria
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- Backman, Helena, 1965- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Department of Obstetrics and Gynecology
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- Gianatti, Emily (författare)
- Department of Endocrinology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
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- Mohan, Viswanathan (författare)
- Dr. Mohan's Diabetes Specialities Centre and Madras Diabetes Research Foundation, Chennai, India
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- Cheung, N. Wah (författare)
- Westmead Hospital and University of Sydney, Sydney, New South Wales, Australia
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- Simmons, David (författare)
- Western Sydney University, Campbelltown, New South Wales, Australia
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548.
- Relaterad länk:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
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- OBJECTIVE: We evaluated associations between early-pregnancy oral glucose tolerance test (OGTT) glucose and complications in the Treatment of Booking Gestational Diabetes Mellitus (TOBOGM) cohort to inform prognostic OGTT thresholds. RESEARCH DESIGN AND METHODS: Individuals with risk factors for hyperglycemia were recruited for an international, multicenter, randomized controlled gestational diabetes mellitus (GDM) (World Health Organization 2013 criteria) treatment trial. A 2-h 75-g OGTT was performed at <20 weeks' gestation. Individuals with early treated hyperglycemia in pregnancy were excluded from the primary analysis. Early OGTT glucose concentrations were analyzed continuously and in glycemic categories (normal, low band, and high band).RESULTS: Overall, 3,645 individuals had an OGTT at (mean ± SD) 15.6 ± 2.5 weeks. For each 1-SD increase in fasting, 1-h, and 2-h glucose values, there were continuous positive associations with late GDM: adjusted odds ratio (aOR) 2.04 (95% CI 1.82-2.27), 3.05 (2.72-3.43), and 2.21 (1.99-2.45), respectively. There were continuous positive associations between 1-h and 2-h glucose and the perinatal composite (birth <37 + 0 weeks, birth trauma, birth weight ≥4,500 g, respiratory distress, phototherapy requirement, stillbirth/neonatal death, and shoulder dystocia), with aOR 1.15 (95% CI 1.04-1.26) and 1.14 (1.04-1.25), respectively, and with large-for-gestational-age offspring, with aOR 1.18 (1.06-1.31) and 1.26 (1.01-1.25), respectively. Significant associations were also observed between 1-h glucose and cesarean section and between fasting and 2-h glucose and neonatal hypoglycemia. In categorical analysis, only the high-band 1-h glucose (≥10.6 mmol/L [191 mg/dL]) predicted the perinatal composite.CONCLUSIONS: There is a continuous positive association between early-pregnancy OGTT glucose and complications. In individuals with hyperglycemia risk factors, only the high-glycemic-band 1-h glucose corresponded to increased risk of major perinatal complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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- Av författaren/redakt...
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Sweeting, Ariann ...
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Enticott, Joanne
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Immanuel, Jincy
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Hague, William M ...
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Teede, Helena
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Nolan, Christoph ...
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Peek, Michael J.
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Flack, Jeff R.
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McLean, Mark
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Wong, Vincent W.
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Hibbert, Emily J ...
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Kautzky-Willer, ...
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Harreiter, Jürge ...
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Backman, Helena, ...
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Gianatti, Emily
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Mohan, Viswanath ...
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Cheung, N. Wah
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Simmons, David
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Diabetes Care
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Örebro universitet