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Eosinophilic inflam...
Eosinophilic inflammation and lung function decline in a long-term follow-up of a large population-based asthma cohort
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- Backman, Helena (author)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN unit, Umeå University, Umeå, Sweden
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- Hedman, Linnea (author)
- Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, OLIN unit, Umea, Sweden
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- Stridsman, Caroline (author)
- Luleå tekniska universitet,Omvårdnad
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- Jansson, Sven-Arne (author)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN unit, Umeå University, Umeå, Sweden
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden
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- Lindberg, Anne (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden
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- Lundback, Bo (author)
- Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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- Rönmark, Eva (author)
- Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, OLIN unit, Umea, Sweden
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The relationship between lung function decline and airway inflammation among asthmatics has important therapeutic implications, but has rarely been studied in large samples or in population-based asthma cohorts.A population-based adult asthma cohort (n=2055) was recruited during 1986-2001 and clinically examined including spirometry. In 2012-2014, all still eligible subjects (n=1425) were invited to a clinical follow-up including spirometry, blood sampling, and a structured interview, and n=1006 participated (55% women, mean age 59y, 32-92y). Linear regression was performed with age, sex, smoking habits, year of first examination, family history of asthma, socioeconomic status, eosinophils (EOS)>=0.3x109/L, and neutrophils (NEUT)>=5.0x109/L as independent variables and pre-bronchodilator FEV1 decline/year (ml and % of predicted [pp], respectively) as dependent. In secondary models, both ICS use at baseline and ICS use at follow-up were also included.The mean annual FEV1 decline in ml (pp) among asthmatics with EOS<0.3, 0.4>EOS>=0.3 and EOS>=0.4x109/L, respectively, was 26ml (0.03pp), 29ml (0.10pp) and 34ml (0.27pp) (p<0.001). In adjusted analyses, EOS>=0.3 was significantly associated with FEV1 decline, both in terms of ml (4ml excess annual decline vs EOS<0.3) and pp. The association between EOS and FEV1 decline in pp, but not ml, remained when additionally adjusted for ICS use. The association with NEUT>=5.0x109/L was less clear.On group level, adult asthmatics with higher levels of eosinophils in blood have a history of excess FEV1 decline compared to asthmatics with lower levels of eosinophil inflammation, independent of other factors such as ICS use.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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