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CYP3A genes and the...
CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment
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- Llop, Sabrina (author)
- CIBER Epidemiology and Public Health (CIBERESP),Jaume I University
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- Tran, N. V. (author)
- University of Rochester
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- Ballester, Ferran (author)
- CIBER Epidemiology and Public Health (CIBERESP),Jaume I University
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- Barbone, Fabio (author)
- Burlo Garofolo Pediatric Institute,University of Udine
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- Sofianou-Katsoulis, Aikaterini (author)
- Institute of Child Health
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- Sunyer, Jordi (author)
- Hospital del Mar Medical Research Institute,CIBER Epidemiology and Public Health (CIBERESP),Pompeu Fabra University,Centre for Research in Environmental Epidemiology
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- Engström, Karin (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Alhamdow, Ayman (author)
- Karolinska Institute
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- Love, Tanzy M (author)
- University of Rochester,CIBER Epidemiology and Public Health (CIBERESP),Jaume I University,University of Udine
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- Watson, Gene E (author)
- University of Rochester
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- Bustamante, Mariona (author)
- Centre for Research in Environmental Epidemiology,CIBER Epidemiology and Public Health (CIBERESP),Hospital del Mar Medical Research Institute,Center for Genomic Regulation (CRG)
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- Murcia, Mario (author)
- CIBER Epidemiology and Public Health (CIBERESP),Jaume I University
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- Iñiguez, Carmen (author)
- Jaume I University,CIBER Epidemiology and Public Health (CIBERESP)
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- Shamlaye, Conrad F (author)
- Ministry of Health, Seychelles
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- Rosolen, Valentina (author)
- University of Udine
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- Mariuz, Marika (author)
- University of Udine
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- Horvat, Milena (author)
- Jožef Stefan Institute
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- Tratnik, Janja Snoj (author)
- Jožef Stefan Institute
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- Mazej, Darja (author)
- Jožef Stefan Institute
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- van Wijngaarden, Edwin (author)
- University of Rochester
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- Davidson, Philip W (author)
- University of Rochester
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- Myers, Gary J. (author)
- University of Rochester
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- Rand, Matthew D. (author)
- University of Rochester
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- Broberg, Karin (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English 9 s.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 105, s. 34-42
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https://doi.org/10.1...
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Abstract
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- Background Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p450 3A (CYP3A) family as candidate MeHg susceptibility genes. Objectives We evaluated whether genetic variation in CYP3A genes influences the association between prenatal exposure to MeHg and child neuropsychological development. Methods The study population included 2639 children from three birth cohort studies: two subcohorts in Seychelles (SCDS) (n = 1160, 20 and 30 months of age, studied during the years 2001–2012), two subcohorts from Spain (INMA) (n = 625, 14 months of age, 2003–2009), and two subcohorts from Italy and Greece (PHIME) (n = 854, 18 months of age, 2006–2011). Total mercury, as a surrogate of MeHg, was analyzed in maternal hair and/or cord blood samples. Neuropsychological development was evaluated using Bayley Scales of Infant Development (BSID). Three functional polymorphisms in the CYP3A family were analyzed: rs2257401 (CYP3A7), rs776746 (CYP3A5), and rs2740574 (CYP3A4). Results There was no association between CYP3A polymorphisms and cord mercury concentrations. The scores for the BSID mental scale improved with increasing cord blood mercury concentrations for carriers of the most active alleles (β[95% CI]: = 2.9[1.53,4.27] for CYP3A7 rs2257401 GG + GC, 2.51[1.04,3.98] for CYP3A5 rs776746 AA + AG and 2.31[0.12,4.50] for CYP3A4 rs2740574 GG + AG). This association was near the null for CYP3A7 CC, CYP3A5 GG and CYP3A4 AA genotypes. The interaction between the CYP3A genes and total mercury was significant (p < 0.05) in European cohorts only. Conclusions Our results suggest that the polymorphisms in CYP3A genes may modify the response to dietary MeHg exposure during early life development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Birth cohort
- Cognitive
- CYP3A polymorphisms
- Methylmercury
- Neurotoxicity
- Prenatal exposure
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Llop, Sabrina
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Tran, N. V.
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Ballester, Ferra ...
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Barbone, Fabio
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Sofianou-Katsoul ...
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Sunyer, Jordi
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show more...
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Engström, Karin
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Alhamdow, Ayman
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Love, Tanzy M
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Watson, Gene E
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Bustamante, Mari ...
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Murcia, Mario
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Iñiguez, Carmen
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Shamlaye, Conrad ...
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Rosolen, Valenti ...
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Mariuz, Marika
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Horvat, Milena
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Tratnik, Janja S ...
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Mazej, Darja
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van Wijngaarden, ...
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Davidson, Philip ...
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Myers, Gary J.
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Rand, Matthew D.
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Broberg, Karin
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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Environment Inte ...
- By the university
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Lund University
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Karolinska Institutet