A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.

• The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Australia

Canada

Carcinoma

Hepatocellular

drug therapy

enzymology

mortality

surgery

Disease-Free Survival

Europe

Humans

Immunosuppressive Agents

therapeutic use

Intracellular Signaling Peptides and Proteins

antagonists & inhibitors

metabolism

Kaplan-Meier Estimate

Liver Neoplasms

drug therapy

enzymology

mortality

surgery

Liver Transplantation

adverse effects

mortality

Prospective Studies

Protein-Serine-Threonine Kinases

antagonists & inhibitors

metabolism

Recurrence

Risk Factors

Sirolimus

therapeutic use

TOR Serine-Threonine Kinases

Time Factors

Transplantation

Homologous

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)