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Anti-beta 2 glycopr...
Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset
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- Elkhalifa, Marwa (author)
- Johns Hopkins University School of Medicine,Alexandria University
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- Orbai, Ana Maria (author)
- Johns Hopkins University School of Medicine
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- Magder, Laurence S. (author)
- University of Maryland School of Medicine
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Alarcón, Graciela S. (author)
- University of Alabama
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- Gordon, Caroline (author)
- University of Birmingham
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- Merrill, Joan (author)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (author)
- Laval University
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Bruce, Ian N. (author)
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- Isenberg, David (author)
- University College London
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- Wallace, Daniel (author)
- University of California, Los Angeles
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Bae, Sang Cheol (author)
- Hanyang University
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- Hanly, John G. (author)
- Dalhousie University
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- Sanchez-Guerrero, Jorge (author)
- University of Toronto
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Clarke, Ann E. (author)
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Manzi, Susan (author)
- Allegheny Health Network
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- Urowitz, Murray (author)
- University of Toronto
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- Gladman, Dafna D. (author)
- University of Toronto
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- Kalunian, Ken (author)
- University of California, San Diego
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- Werth, Victoria P. (author)
- Hospital of the University of Pennsylvania
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- Zoma, Asad (author)
- Hairmyres Hospital
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- Bernatsky, Sasha (author)
- McGill University Health Center
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Khamashta, Munther (author)
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- Jacobsen, SØren (author)
- Copenhagen University Hospital
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- Buyon, Jill P. (author)
- New York University
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- Dooley, Mary Anne (author)
- University of North Carolina
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- Vollenhoven, Ronald van (author)
- Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam
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- Ginzler, Ellen (author)
- SUNY Downstate Health Sciences University
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- Stoll, Thomas (author)
- Cantonal Hospital of Olten
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- Peschken, Christine (author)
- University of Manitoba
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- Jorizzo, Joseph L. (author)
- Weill Cornell Medical College
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- Callen, Jeffery P. (author)
- University of Louisville Health Sciences Center
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- Lim, Sam (author)
- Emory University
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Inanc, Murat (author)
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Rahman, Anisur (author)
- University College London
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- Steinsson, Kristjan (author)
- National University Hospital of Iceland
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- Franks, Andrew G. (author)
- New York University
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(creator_code:org_t)
- 2021-05-06
- 2021
- English 6 s.
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In: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 30:8, s. 1283-1288
- Related links:
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http://dx.doi.org/10...
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https://discovery.uc...
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Abstract
Subject headings
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- Objective: Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-beta 2-glycoprotein I IgA in SLE versus other rheumatic diseases. In addition, we examined the association between anti-beta 2 glycoprotein I IgA and disease manifestations in SLE. Methods: The dataset consisted of 1384 patients, 657 with a consensus physician diagnosis of SLE and 727 controls with other rheumatic diseases. Anti-beta 2 glycoprotein I isotypes were measured by ELISA. Patients with a consensus diagnosis of SLE were compared to controls with respect to presence of anti-beta 2 glycoprotein I. Among patients with SLE, we assessed the association between anti-beta 2 glycoprotein I IgA and clinical manifestations. Results: The prevalence of anti-beta 2 glycoprotein I IgA was 14% in SLE patients and 7% in rheumatic disease controls (odds ratio, OR 2.3, 95% CI: 1.6, 3.3). It was more common in SLE patients who were younger patients and of African descent (p = 0.019). Eleven percent of SLE patients had anti-beta 2 glycoprotein I IgA alone (no anti-beta 2 glycoprotein I IgG or IgM). There was a significant association between anti-beta 2 glycoprotein I IgA and anti-dsDNA (p = 0.001) and the other antiphospholipid antibodies (p = 0.0004). There was no significant correlation of anti-beta 2 glycoprotein I IgA with any of the other ACR or SLICC clinical criteria for SLE. Those with anti-beta 2 glycoprotein I IgA tended to have a history of thrombosis (12% vs 6%, p = 0.071), but the difference was not statistically significant. Conclusion: We found the anti-beta 2 glycoprotein I IgA isotype to be more common in patients with SLE and in particular, with African descent. It could occur alone without other isotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- anti-beta 2 glycoprotein IgA
- antiphospholipid antibodies
- classification criteria
- Systemic lupus erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Elkhalifa, Marwa
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Orbai, Ana Maria
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Magder, Laurence ...
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Petri, Michelle
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Alarcón, Graciel ...
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Gordon, Caroline
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show more...
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Merrill, Joan
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Fortin, Paul R.
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Bruce, Ian N.
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Isenberg, David
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Wallace, Daniel
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Nived, Ola
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Ramsey-Goldman, ...
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Bae, Sang Cheol
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Hanly, John G.
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Sanchez-Guerrero ...
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Clarke, Ann E.
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Aranow, Cynthia
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Manzi, Susan
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Urowitz, Murray
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Gladman, Dafna D ...
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Kalunian, Ken
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Werth, Victoria ...
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Zoma, Asad
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Bernatsky, Sasha
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Khamashta, Munth ...
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Jacobsen, SØren
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Buyon, Jill P.
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Dooley, Mary Ann ...
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Vollenhoven, Ron ...
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Ginzler, Ellen
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Stoll, Thomas
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Peschken, Christ ...
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Jorizzo, Joseph ...
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Callen, Jeffery ...
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Lim, Sam
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Inanc, Murat
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Kamen, Diane L.
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Rahman, Anisur
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Steinsson, Krist ...
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Franks, Andrew G ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Lupus
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Lund University