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Prediction of Damag...
Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index
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- Legge, Alexandra (author)
- Dalhousie University
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- Kirkland, Susan (author)
- Dalhousie University
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- Rockwood, Kenneth (author)
- Dalhousie University
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- Andreou, Pantelis (author)
- Dalhousie University
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- Bae, Sang Cheol (author)
- Hanyang University
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- Gordon, Caroline (author)
- University of Birmingham
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Sanchez-Guerrero, Jorge (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Wallace, Daniel J. (author)
- University of California, Los Angeles
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- Bernatsky, Sasha (author)
- McGill University
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- Clarke, Ann E. (author)
- University of Calgary
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University
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- Fortin, Paul R. (author)
- Laval University
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- Gladman, Dafna D. (author)
- University of Toronto
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- Urowitz, Murray B. (author)
- University of Toronto
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- Bruce, Ian N. (author)
- University of Manchester
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- Isenberg, David A. (author)
- Royal Free Hospital
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- Rahman, Anisur (author)
- Royal Free Hospital
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- Alarcón, Graciela S. (author)
- University of Alabama
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Khamashta, Munther A. (author)
- King's College London
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- Dooley, M. A. (author)
- University of North Carolina
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Manzi, Susan (author)
- Allegheny Health Network
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- Zoma, Asad A. (author)
- Hairmyres Hospital
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (author)
- Hospital de Cruces
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- Lim, S. Sam (author)
- Emory University
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- Inanc, Murat (author)
- Istanbul University
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Karolinska Institute
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- Jonsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ramos-Casals, Manuel (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Kalunian, Kenneth C. (author)
- University of California, Berkeley
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- Jacobsen, Soren (author)
- Copenhagen University Hospital
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- Peschken, Christine A. (author)
- University of Manitoba
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- Askanase, Anca (author)
- Indian Institute of Technology
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- Hanly, John G. (author)
- Dalhousie University
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(creator_code:org_t)
- 2020-02-12
- 2020
- English 9 s.
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In: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 72:4, s. 658-666
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http://dx.doi.org/10...
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https://discovery.uc...
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https://lup.lub.lu.s...
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Abstract
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- Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. Methods: The baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics. Results: The 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9–1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13–1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents. Conclusion: Our findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (subject category)
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- By the author/editor
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Legge, Alexandra
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Kirkland, Susan
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Rockwood, Kennet ...
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Andreou, Panteli ...
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Bae, Sang Cheol
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Gordon, Caroline
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Wallace, Daniel ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Merrill, Joan T.
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Ginzler, Ellen M ...
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Fortin, Paul R.
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Gladman, Dafna D ...
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Urowitz, Murray ...
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Bruce, Ian N.
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Isenberg, David ...
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Rahman, Anisur
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Alarcón, Graciel ...
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Petri, Michelle
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Khamashta, Munth ...
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Dooley, M. A.
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Ramsey-Goldman, ...
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Manzi, Susan
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Zoma, Asad A.
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Inanc, Murat
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van Vollenhoven, ...
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Jonsen, Andreas
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Nived, Ola
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Ramos-Casals, Ma ...
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Kamen, Diane L.
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Askanase, Anca
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Hanly, John G.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Arthritis and Rh ...
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Lund University
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Karolinska Institutet