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Intravenous Infusio...
Intravenous Infusions of Purified Alpha-1 Antitripsyn Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient
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Blanco Blanco, Ignacio (författare)
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Astudillo, Aurora (författare)
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Dominguez Iglesias, Francisco (författare)
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- Janciauskiene, Sabina (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups
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Carcaba Fernandez, Victoriano (författare)
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Gallo Alvaro, Cesar (författare)
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Canto Argiz, Hortensia (författare)
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de Serres, Frederick Joseph (författare)
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Fernandez Bustillo, Enrique (författare)
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(creator_code:org_t)
- 2010-05-13
- 2010
- Engelska.
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Ingår i: Journal of Musculoskeletal Pain. - : Informa UK Limited. - 1540-7012 .- 1058-2452. ; 18:2, s. 167-172
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: An MZ phenotype alpha-1 antitrypsin [AAT] deficiency and fibromyalgia syndrome [FMS] patient participated in a trial with AAT-intravenous augmentationtherapy [AAT-IV-AT] after failure of conventional therapeutic measures. Three quadricep biopsies were performed at different stages. The first one showed large aggregates of AAT and ubiquitin in myocytes and blood vessels, and moderate muscle atrophy, before AAT-IV-AT. The two remaining biopsies were performed while receiving AAT-IV-AT. Findings: Remarkably good clinical response and histological improvement in the follow-up biopsies. Conclusions: The clinical and histopathological efficacy of AAT-IV-AT evidenced in this patient should open new perspectives of research and management of AAT deficiency and FMS patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- alpha-1 antitrypsin augmentation therapy
- deficiency
- alpha-1 antitrypsin
- Fibromyalgia syndrome
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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