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Sökning: onr:"swepub:oai:DiVA.org:umu-189995" > Breast Cancer Risk ...

Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Clendenen, Tess V. (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States
Ge, Wenzhen (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States
Koenig, Karen L. (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States
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Afanasyeva, Yelena (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States
Agnoli, Claudia (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
Bertone-Johnson, Elizabeth (författare)
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States
Brinton, Louise A. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Darvishian, Farbod (författare)
Pathology, New York University School of Medicine, NY, New York, United States; Perlmutter Cancer Center, New York University School of Medicine, NY, New York, United States
Dorgan, Joanne F. (författare)
Department of Epidemiology and Public Health, University of Maryland School of Medicine, MD, Baltimore, United States
Eliassen, A. Heather (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
Falk, Roni T. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Hallmans, Göran, 1947- (författare)
Umeå universitet,Näringsforskning
Hankinson, Susan E. (författare)
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
Hoffman-Bolton, Judith (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Key, Timothy J. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Krogh, Vittorio (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
Nichols, Hazel B. (författare)
Department of Epidemiology, University of North Carolina, NC, Chapel Hill, United States
Sandler, Dale P. (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
Schoemaker, Minouk J. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
Sluss, Patrick M. (författare)
Department of Pathology, Harvard Medical School, MA, Boston, United States
Sund, Malin (författare)
Umeå universitet,Kirurgi,Department of Surgery, Umeå University Hospital, Umeå, Sweden
Swerdlow, Anthony J. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States; Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, United States
Liu, Mengling (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States; Perlmutter Cancer Center, New York University School of Medicine, NY, New York, United States
Zeleniuch-Jacquotte, Anne (författare)
Department of Population Health, New York University School of Medicine, NY, New York, United States; Perlmutter Cancer Center, New York University School of Medicine, NY, New York, United States
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 (creator_code:org_t)
2021-06-22
2021
Engelska.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 106:11, s. E4542-E4553
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Context: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.Objective: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.Methods: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.Results: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

AMH correlates
anti-Müllerian hormone
breast cancer risk factors

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