Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

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Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse

Tay, Nicole (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Macare, Christine (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Liu, Yun (författare): Fudan Univ, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Sch Basic Med Sci, Shanghai, Peoples R China

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Ruggeri, Barbara (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Jia, Tianye (författare): Karolinska Institutet

Chu, Congying (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Biondo, Francesca (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Ing, Alex (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Luo, Qiang (författare): Fudan Univ, Sch Life Sci, Shanghai, Peoples R China;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China

Sarkisyan, Daniil (författare): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Banaschewski, Tobias (författare): Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

Barker, Gareth J. (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Bokde, Arun L. W. (författare): Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland

Bromberg, Uli (författare): Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

Büchel, Christian (författare): Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

Quinlan, Erin Burke (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Desrivieres, Sylvane (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

Flor, Herta (författare): Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Univ Mannheim, Dept Psychol, Sch Social Sci, Mannheim, Germany

Frouin, Vincent (författare): Univ Paris Saclay, NeuroSpin, Gif Sur Yvette, France

Garavan, Hugh (författare): Univ Vermont, Dept Psychiat, Burlington, VT USA;Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

Gowland, Penny (författare): Univ Nottingham, Sir Peter Mansfield Imaging Ctr Sch Phys, Nottingham, England

Heinz, Andreas (författare): Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany

Ittermann, Bernd (författare): Phys Tech Bundesanstalt, Berlin, Germany

Martinot, Jean-Luc (författare): Univ Paris 05, Univ Paris Sud Paris Saclay, Unit 1000 Neuroimaging & Psychiat, DIGITEO Labs,INSERM, Gif Sur Yvette, France;Cochin Hosp, Maison Solenn, Paris, France

Artiges, Eric (författare): Univ Paris Saclay, Univ Paris Sud, DIGITEO Labs, INSERM, Gif Sur Yvette, France;Orsay Hosp, Dept Psychiat, Orsay, France

Nees, Frauke (författare): Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland;Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Nees German Res Fdn, Bonn, Germany

Orfanos, Dimitri Papadopoulos (författare): Univ Paris Saclay, NeuroSpin, Gif Sur Yvette, France

Paus, Tomas (författare): Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Hosp & Dept Psychol, Toronto, ON, Canada;Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Dept Psychiat, Toronto, ON, Canada

Poustka, Luise (författare): Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Gottingen, Germany;Med Univ Vienna, Clin Child & Adolescent Psychiat, Vienna, Austria

Hohmann, Sarah (författare): Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

Fröhner, Juliane H. (författare): Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

Smolka, Michael N. (författare): Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

Walter, Henrik (författare): Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany

Whelan, Robert (författare): Trinity Coll Dublin, Sch Psychol, Dublin, Ireland;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

Frieling, Helge (författare): Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany

Bleich, Stefan (författare): Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany

Barker, Edward D. (författare): Kings Coll London, Ctr Neuroimaging Sci, Inst Psychiat Psychol & Neurosci, London, England

Syvänen, Ann-Christine, 1950- (författare): Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab

Rüegg, Joelle (författare): Karolinska Institutet

Ekström, Tomas J. (författare): Karolinska Inst, Dept Clin Neurosci, Ctr Mol Med, Stockholm, Sweden

Bakalkin, Georgy (författare): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Schumann, Gunter (författare): Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England

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(creator_code:org_t)

AMER PSYCHIATRIC PUBLISHING, INC, 2019
2019
Engelska.
Ingår i: American Journal of Psychiatry. - : AMER PSYCHIATRIC PUBLISHING, INC. - 0002-953X .- 1535-7228. ; 176:2, s. 146-155

Relaterad länk:: https://ajp.psychiat...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

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Objective: Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population.Methods: A methylome-wide analysis of differentially methylated regions was used to examine a sample of 1,287 14-year-old adolescents (50.7% of them female) from the European IMAGEN study. The Illumina 450k array was used to assess DNA methylation, pyrosequencing was used for technical replication, and linear regression analyses were used to identify associations with psychosocial stress and substance use (alcohol and tobacco). Findings were replicated by pyrosequencing a test sample of 413 participants from the IMAGEN study.Results: Hypermethylation in the sterile alpha motif/pointed domain containing the ETS transcription factor (SPDEF) gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which in turn was associated with the frequency of alcohol and tobacco use. SPDEF was involved in the regulation of trans-genes linked to substance use.Conclusions: Taken together, the study findings describe a novel epigenetic mechanism that helps explain how psychosocial stress exposure influences adolescent substance abuse.

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Av författaren/redakt...: Tay, Nicole; Macare, Christin ...; Liu, Yun; Ruggeri, Barbara; Jia, Tianye; Chu, Congying; visa fler...; Biondo, Francesc ...; Ing, Alex; Luo, Qiang; Sarkisyan, Danii ...; Banaschewski, To ...; Barker, Gareth J ...; Bokde, Arun L. W ...; Bromberg, Uli; Büchel, Christia ...; Quinlan, Erin Bu ...; Desrivieres, Syl ...; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-L ...; Artiges, Eric; Nees, Frauke; Orfanos, Dimitri ...; Paus, Tomas; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane ...; Smolka, Michael ...; Walter, Henrik; Whelan, Robert; Frieling, Helge; Bleich, Stefan; Barker, Edward D ...; Syvänen, Ann-Chr ...; Rüegg, Joelle; Ekström, Tomas J ...; Bakalkin, Georgy; Schumann, Gunter; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: American Journal ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse

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