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Plasma carotenoids ...
Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M. (author)
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Bueno-de-Mesquita, H. Bas (author)
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Kampman, Ellen (author)
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show more...
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Aben, Katja K. H. (author)
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Buechner, Frederike L. (author)
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Jansen, Eugene H. J. M. (author)
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van Gils, Carla H. (author)
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- Egevad, Lars (author)
- Karolinska Institutet
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Roswall, Nina (author)
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Boutron-Ruault, Marie Christine (author)
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Kvaskoff, Marina (author)
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Perquier, Florence (author)
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Kaaks, Rudolf (author)
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Chang-Claude, Jenny (author)
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Weikert, Steffen (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Dilis, Vardis (author)
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Palli, Domenico (author)
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Pala, Valeria (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Peeters, Petra H. M. (author)
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Gram, Inger T. (author)
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Skeie, Guri (author)
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Huerta, Jose Maria (author)
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Barricarte, Aurelio (author)
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Quiros, Jose Ramon (author)
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Sanchez, Maria Jose (author)
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Buckland, Genevieve (author)
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Larranaga, Nerea (author)
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- Ehrnström, Roy (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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- Wallström, Peter (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi,Njurcancer
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Key, Timothy J. (author)
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Allen, Naomi E. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Brennan, Paul (author)
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Riboli, Elio (author)
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Kiemeney, Lambertus A. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 96:4, s. 902-910
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
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- Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Ros, Martine M.
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Bueno-de-Mesquit ...
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Kampman, Ellen
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Aben, Katja K. H ...
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Buechner, Freder ...
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Jansen, Eugene H ...
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show more...
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van Gils, Carla ...
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Egevad, Lars
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Overvad, Kim
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Tjonneland, Anne
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Roswall, Nina
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Boutron-Ruault, ...
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Kvaskoff, Marina
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Perquier, Floren ...
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Kaaks, Rudolf
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Chang-Claude, Je ...
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Weikert, Steffen
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Dilis, Vardis
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Palli, Domenico
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Pala, Valeria
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Sacerdote, Carlo ...
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Tumino, Rosario
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Panico, Salvator ...
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Peeters, Petra H ...
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Gram, Inger T.
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Skeie, Guri
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Huerta, Jose Mar ...
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Barricarte, Aure ...
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Quiros, Jose Ram ...
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Sanchez, Maria J ...
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Buckland, Genevi ...
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Larranaga, Nerea
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Ehrnström, Roy
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Wallström, Peter
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Ljungberg, Börje
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Hallmans, Göran
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Key, Timothy J.
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Allen, Naomi E.
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Khaw, Kay-Tee
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Wareham, Nick
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Brennan, Paul
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Riboli, Elio
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Kiemeney, Lamber ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet