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Sökning: onr:"swepub:oai:DiVA.org:umu-216170" > Combining Asian and...

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Thomas, Minta (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Biostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, United States
Rosenthal, Elisabeth A. (författare)
Department of Medicine (Medical Genetics), University of Washington Medical Center, WA, Seattle, United States
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Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Schmit, Stephanie L. (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, United States
Timofeeva, Maria N. (författare)
Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Germany
Chen, Zhishan (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Fernandez-Rozadilla, Ceres (författare)
Instituto de Investigacion Sanitaria de Santiago (IDIS), Choupana sn, Santiago de Compostela, Spain; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, United Kingdom
Law, Philip J. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Reseach, London, United Kingdom
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Carreras-Torres, Robert (författare)
Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Girona, Salt, Spain
Diez-Obrero, Virginia (författare)
Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
van Duijnhoven, Franzel J. B. (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
Jiang, Shangqing (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Shin, Aesun (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea
Wolk, Alicja (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Phipps, Amanda I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Gsur, Andrea (författare)
.Center for Cancer Research, Medical University Vienna, Vienna, Austria
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Zauber, Ann G. (författare)
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, New York, United States
Wu, Anna H. (författare)
University of Southern California, Preventative Medicine, CA, Los Angeles, United States
Lindblom, Annika (författare)
Karolinska Institutet
Um, Caroline Y. (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
Tangen, Catherine M. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Gignoux, Chris (författare)
Colorado Center for Personalized Medicine, University of Colorado - Anschutz Medical Campus, CO, Aurora, United States
Newton, Christina (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
Haiman, Christopher A. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Bishop, D. Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
Crosslin, David R. (författare)
Department of Bioinformatics and Medical Education, University of Washington Medical Center, WA, Seattle, United States
Conti, David V. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Kim, Dong-Hyun (författare)
Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea
Hauser, Elizabeth (författare)
VA Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Health Care System, NC, Durham, United States; Duke Molecular Physiology Institute, Duke University Medical Center, NC, Durham, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Siegel, Erin (författare)
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
Schumacher, Fredrick R. (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Hampel, Heather (författare)
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany
Oze, Isao (författare)
.Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Oh, Jae Hwan (författare)
.Research Institute and Hospital, National Cancer Center, South Korea, Goyang, South Korea
Lee, Jeffrey K. (författare)
.Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, CA, San Francisco, United States; Department of Pathology, University of Michigan, MI, Ann Arbor, United States
Schneider, Jennifer L. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Kim, Jeongseon (författare)
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Zheng, Jiayin (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hampe, Jochen (författare)
Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
Greenson, Joel (författare)
Department of Pathology, University of Michigan, MI, Ann Arbor, United States
Hopper, John L. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
Palmer, Julie R. (författare)
Slone Epidemiology Center, School of Medicine, Boston University, MA, Boston, United States
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Matsuo, Keitaro (författare)
Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
Matsuda, Koichi (författare)
Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Jung, Keum Ji (författare)
Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Vodickova, Ludmila (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Bujanda, Luis (författare)
Department of Gastroenterology, Biodonostia Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Matejcic, Marco (författare)
Moffitt Cancer Center, FL, Tampa, United States
Jenkins, Mark A. (författare)
University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
D’Amato, Mauro (författare)
Department of Medicine and Surgery, LUM University, Camassima, Italy; Gastrointestinal Genetics Lab, CIC bioGUNE-BRTA, Derio, Spain
Wang, Meilin (författare)
Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John’s, Canada
Kim, Michelle (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Song, Mingyang (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Departments of Epidemiology and Nutrition, Harvard TH Chan School of Public Health, MA, Boston, United States
Iwasaki, Motoki (författare)
Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Du, Mulong (författare)
Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Udaltsova, Natalia (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Sawada, Norie (författare)
Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Cai, Qiuyin (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Pearlman, Rachel (författare)
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Pai, Rish K. (författare)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Steinfelder, Robert S. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Haile, Robert W. (författare)
Samuel Oschin Comprehensive Cancer Institute, CEDARS-SINAI, CA, Los Angeles, United States
Vandenputtelaar, Rosita (författare)
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Prentice, Ross L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Küry, Sébastien (författare)
Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France
Castellví-Bel, Sergi (författare)
Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Tsugane, Shoichiro (författare)
Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Lee, Soo Chin (författare)
National University Cancer Institute, Singapore, Singapore
Brezina, Stefanie (författare)
.Center for Cancer Research, Medical University Vienna, Vienna, Austria
Weinstein, Stephanie J. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Chanock, Stephen J. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Jee, Sun Ha (författare)
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
Kweon, Sun-Seog (författare)
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
Vadaparampil, Susan (författare)
Departments of Epidemiology and Nutrition, Harvard TH Chan School of Public Health, MA, Boston, United States
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Yamaji, Taiki (författare)
Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
Vymetalkova, Veronika (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Jia, Wei-Hua (författare)
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China
Shu, Xiao-Ou (författare)
Vanderbilt University Medical Center, TN, Nashville, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Ahn, Yoon-Ok (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea
Stadler, Zsofia K. (författare)
Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Li, Christopher I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Meester, Reinier (författare)
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Moreno, Victor (författare)
Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
Figueiredo, Jane C. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Lansdorp Vogelaar, Iris (författare)
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Dunlop, Malcolm G. (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Germany
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States
Hayes, Richard B. (författare)
Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States
Pharoah, Paul D. P. (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Houlston, Richard S. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Reseach, London, United Kingdom
Jarvik, Gail P. (författare)
Department of Medicine (Medical Genetics), University of Washington Medical Center, WA, Seattle, United States
Tomlinson, Ian P. (författare)
Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, United Kingdom
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Corley, Douglas A. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Gastroenterology, Kaiser Permanente Medical Center, CA, San Francisco, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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 (creator_code:org_t)
Springer Nature, 2023
2023
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.

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MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Wu, Anna H.
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Um, Caroline Y.
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Qu, Conghui
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Kim, Jeongseon
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Bujanda, Luis
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Matejcic, Marco
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Kim, Michelle
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