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The acute effects o...
The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD(3)
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Bustamante, Mariona (author)
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Hernandez-Ferrer, Caries (author)
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Sarria, Yaris (author)
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Harrison, Graham I. (author)
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Nonell, Lara (author)
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- Kang, Wenjing (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab)
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- Friedlander, Marc R. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab)
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Estivill, Xavier (author)
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Gonzalez, Juan R. (author)
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Nieuwenhuijsen, Mark (author)
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Young, Antony R. (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 159, s. 239-248
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D-3 [250HD(3)] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 250HD(3) levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 250HD(3) and blood cell subpopulations.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Solar ultraviolet radiation
- Vitamin D
- Blood
- Gene expression
- MiRNA expression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bustamante, Mari ...
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Hernandez-Ferrer ...
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Sarria, Yaris
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Harrison, Graham ...
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Nonell, Lara
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Kang, Wenjing
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show more...
-
Friedlander, Mar ...
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Estivill, Xavier
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Gonzalez, Juan R ...
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Nieuwenhuijsen, ...
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Young, Antony R.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environmental Re ...
- By the university
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Stockholm University