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Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory

Brunner, Eric J. (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
Maruyama, Koutatsu (författare)
Institute of Epidemiology and Health Care, University College London, London, UK; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Japan
Shipley, Martin (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
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Cable, Noriko (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
Iso, Hiroyasu (författare)
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Hiyoshi, Ayako, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics
Stallone, Daryth (författare)
Nutrepol, Merritt Island, FL, USA
Kumari, Meena (författare)
Institute of Epidemiology and Health Care, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK
Tabak, Adam (författare)
Institute of Epidemiology and Health Care, University College London, London, UK; Department of Internal Medicine and Ocology, Faculty of Medicine, Semmelweis University, Budapest, Hungary; Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Singh-Manoux, Archana (författare)
Institute of Epidemiology and Health Care, University College London, London, UK; Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris, Paris, France
Wilson, John (författare)
North Devon Medical Education Centre, North Devon District Hospital, Barnstaple, UK
Langenberg, Claudia (författare)
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
Wareham, Nick (författare)
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
Boniface, David (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
Hingorani, Aroon (författare)
Institute of Cardiovascular Science, University College London, London, UK
Kivimäki, Mika (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
Llewellyn, Clare (författare)
Institute of Epidemiology and Health Care, University College London, London, UK
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 (creator_code:org_t)
2021-01-14
2021
Engelska.
Ingår i: International Journal of Obesity. - : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 45, s. 758-765
Relaterad länk:
https://doi.org/10.1...
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https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of 'disinhibition', indicative of opportunistic eating or overeating and 'hunger' which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex.RESULTS: Disinhibition was associated with higher BMI (beta = 2.96; 95% CI: 2.66-3.25 kg/m(2)), and accounted for 34% of the genetically-linked BMI difference at age 45. Hunger was also associated with higher BMI (beta = 1.20; 0.82-1.59 kg/m(2)) during mid-life and slightly steeper weight gain, but did not attenuate the effect of disinhibition. CONCLUSIONS: Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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