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Biological Activiti...
Biological Activities of the Essential Oil from Erigeron floribundus
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Petrelli, Riccardo (author)
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Orsomando, Giuseppe (author)
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Sorci, Leonardo (author)
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Maggi, Filippo (author)
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- Ranjbarian, Farahnaz (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Nya, Prosper C. Biapa (author)
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Petrelli, Dezemona (author)
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Vitali, Luca A. (author)
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Lupidi, Giulio (author)
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Quassinti, Luana (author)
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Bramucci, Massimo (author)
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- Hofer, Anders (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Cappellacci, Loredana (author)
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(creator_code:org_t)
- 2016-08-13
- 2016
- English.
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In: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 21:8
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 mu g/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 mu g/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 mu g/mL with the essential oil and 5.6 mu g/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 mu g/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 mu mol.TE/g).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Erigeron floribundus
- essential oil
- antimicrobial
- NadD
- Trypanosoma brucei
- cytotoxicity
- tioxidant
- limonene
- caryophyllene oxide
Publication and Content Type
- ref (subject category)
- art (subject category)
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Petrelli, Riccar ...
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Orsomando, Giuse ...
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Sorci, Leonardo
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Maggi, Filippo
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Ranjbarian, Fara ...
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Nya, Prosper C. ...
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Petrelli, Dezemo ...
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Vitali, Luca A.
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Lupidi, Giulio
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Quassinti, Luana
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Bramucci, Massim ...
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Hofer, Anders
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Cappellacci, Lor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Molecules
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Umeå University