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Significance and Translational Value of High-Frequency Cortico-Basal Ganglia Oscillations in Parkinson's Disease

Petersson, Per (author)
Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Department of Experimental Medical Science, The Group for Integrative Neurophysiology and Neurotechnology, Lund University, Lund, Sweden,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Integrative Neurophysiology,Lund University Research Groups
Halje, Pär (author)
Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Department of Experimental Medical Science, The Group for Integrative Neurophysiology and Neurotechnology, Lund University, Lund, Sweden,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Integrative Neurophysiology,Lund University Research Groups
Cenci, M. Angela (author)
Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups
 (creator_code:org_t)
IOS Press, 2019
2019
English.
In: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 9:1, s. 183-196
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states. We review the occurrence of different types of fast oscillations and the evidence supporting their pathophysiological role. We also provide a general discussion on the definition, possible mechanisms, and translational value of synchronized oscillations of different frequencies in cortico-basal ganglia structures. Revealing how oscillatory phenomena are caused and spread in cortico-basal ganglia-thalamocortical networks will offer a key to unlock the neural codes of both motor and non-motor symptoms in PD. In preclinical therapeutic research, recording of oscillatory neural activities holds the promise to unravel mechanisms of action of current and future treatments.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Pathophysiology
movement disorders
bradykinesia
dyskinesia
animal models
cortex
thalamus
animal models
bradykinesia
cortex
dyskinesia
movement disorders
Pathophysiology
thalamus

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ref (subject category)
art (subject category)

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Petersson, Per
Halje, Pär
Cenci, M. Angela
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
Articles in the publication
Journal of Parki ...
By the university
Umeå University
Lund University

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