Tyck till om SwePub Sök
här!
Search: WFRF:(Chiotis Konstantinos) >
Imaging in-vivo tau...
Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm
-
- Chiotis, Konstantinos (author)
- Karolinska Institutet
-
- Saint-Aubert, Laure (author)
- Karolinska Institutet
-
Savitcheva, Irina (author)
-
show more...
-
- Jelic, Vesna (author)
- Karolinska Institutet
-
Andersen, Pia (author)
-
- Jonasson, My (author)
- Uppsala universitet,Radiologi
-
- Eriksson, Jonas (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning
-
- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
-
- Almkvist, Ove (author)
- Stockholms universitet,Biologisk psykologi,Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden
-
- Wall, Anders (author)
- Uppsala universitet,Radiologi
-
- Antoni, Gunnar (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning
-
- Nordberg, Agneta (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2016-03-21
- 2016
- English.
-
In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 43:9, s. 1686-1699
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://link.springe...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Purpose The aim of this study was to explore the cerebral distribution of the tau-specific PET tracer [F-18]THK5317 (also known as (S)-[F-18]THK5117) retention in different stages of Alzheimer's disease; and study any associations with markers of hypometabolism and amyloid-beta deposition. Methods Thirty-three individuals were enrolled, including nine patients with Alzheimer's disease dementia, thirteen with mild cognitive impairment (MCI), two with non-Alzheimer's disease dementia, and nine healthy controls (five young and four elderly). In a multi-tracer PET design [F-18]THK5317, [C-11] Pittsburgh compound B ([C-11]PIB), and [F-18]FDG were used to assess tau pathology, amyloid-beta deposition and cerebral glucose metabolism, respectively. The MCI patients were further divided into MCI [C-11]PIB-positive (n=11) and MCI [C-11]PIB-negative (n=2) groups. Results Test-retest variability for [F-18]THK5317-PET was very low (1.17-3.81 %), as shown by retesting five patients. The patients with prodromal (MCI [C-11]PIB-positive) and dementia-stage Alzheimer's disease had significantly higher [F-18]THK5317 retention than healthy controls (p=0.002 and p=0.001, respectively) in areas exceeding limbic regions, and their discrimination from this control group (using the area under the curve) was >98 %. Focal negative correlations between [F-18]THK5317 retention and [F-18]FDG uptake were observed mainly in the frontal cortex, and focal positive correlations were found between [F-18]THK5317 and [C-11] PIB retentions isocortically. One patient with corticobasal degeneration syndrome and one with progressive supranuclear palsy showed no [C-11]PIB but high [F-18]THK5317 retentions with a different regional distribution from that in Alzheimer's disease patients. Conclusions The tau-specific PET tracer [F-18]THK5317 images in vivo the expected regional distribution of tau pathology. This distribution contrasts with the different patterns of hypometabolism and amyloid-beta deposition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Positron emission tomography
- Alzheimer's disease
- Tau
- Neurofibrillary tangles
- THK5317
- Other dementia
- Non-AD
- Amyloid PET
- FDG
- PIB
- Psychology
- psykologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Chiotis, Konstan ...
-
Saint-Aubert, La ...
-
Savitcheva, Irin ...
-
Jelic, Vesna
-
Andersen, Pia
-
Jonasson, My
-
show more...
-
Eriksson, Jonas
-
Lubberink, Mark
-
Almkvist, Ove
-
Wall, Anders
-
Antoni, Gunnar
-
Nordberg, Agneta
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
European Journal ...
- By the university
-
Stockholm University
-
Uppsala University
-
Karolinska Institutet