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Search: WFRF:(Chow Wong Ho) > (2010-2014) > (2011) > Genome-wide associa...

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Purdue, Mark P (author)
Johansson, Mattias (author)
International Agency for Research on Cancer (IARC), Lyon, France
Zelenika, Diana (author)
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Toro, Jorge R (author)
Scelo, Ghislaine (author)
Moore, Lee E (author)
Prokhortchouk, Egor (author)
Wu, Xifeng (author)
Kiemeney, Lambertus A (author)
Gaborieau, Valerie (author)
Jacobs, Kevin B (author)
Chow, Wong-Ho (author)
Zaridze, David (author)
Matveev, Vsevolod (author)
Lubinski, Jan (author)
Trubicka, Joanna (author)
Szeszenia-Dabrowska, Neonila (author)
Lissowska, Jolanta (author)
Rudnai, Péter (author)
Fabianova, Eleonora (author)
Bucur, Alexandru (author)
Bencko, Vladimir (author)
Foretova, Lenka (author)
Janout, Vladimir (author)
Boffetta, Paolo (author)
Colt, Joanne S (author)
Davis, Faith G (author)
Schwartz, Kendra L (author)
Banks, Rosamonde E (author)
Selby, Peter J (author)
Harnden, Patricia (author)
Berg, Christine D (author)
Hsing, Ann W (author)
Grubb, Robert L (author)
Boeing, Heiner (author)
Vineis, Paolo (author)
Clavel-Chapelon, Françoise (author)
Palli, Domenico (author)
Tumino, Rosario (author)
Krogh, Vittorio (author)
Panico, Salvatore (author)
Duell, Eric J (author)
Quirós, José Ramón (author)
Sanchez, Maria-José (author)
Navarro, Carmen (author)
Ardanaz, Eva (author)
Dorronsoro, Miren (author)
Khaw, Kay-Tee (author)
Allen, Naomi E (author)
Bueno-de-Mesquita, H Bas (author)
Peeters, Petra H M (author)
Trichopoulos, Dimitrios (author)
Linseisen, Jakob (author)
Ljungberg, Börje (author)
Umeå universitet,Urologi och andrologi
Overvad, Kim (author)
Tjønneland, Anne (author)
Romieu, Isabelle (author)
Riboli, Elio (author)
Mukeria, Anush (author)
Shangina, Oxana (author)
Stevens, Victoria L (author)
Thun, Michael J (author)
Diver, W Ryan (author)
Gapstur, Susan M (author)
Pharoah, Paul D (author)
Easton, Douglas F (author)
Albanes, Demetrius (author)
Weinstein, Stephanie J (author)
Virtamo, Jarmo (author)
Vatten, Lars (author)
Hveem, Kristian (author)
Njølstad, Inger (author)
Tell, Grethe S (author)
Stoltenberg, Camilla (author)
Kumar, Rajiv (author)
Koppova, Kvetoslava (author)
Cussenot, Olivier (author)
Benhamou, Simone (author)
Oosterwijk, Egbert (author)
Vermeulen, Sita H (author)
Aben, Katja K H (author)
van der Marel, Saskia L (author)
Ye, Yuanqing (author)
Wood, Christopher G (author)
Pu, Xia (author)
Mazur, Alexander M (author)
Boulygina, Eugenia S (author)
Chekanov, Nikolai N (author)
Foglio, Mario (author)
Lechner, Doris (author)
Gut, Ivo (author)
Heath, Simon (author)
Blanche, Hélène (author)
Hutchinson, Amy (author)
Thomas, Gilles (author)
Wang, Zhaoming (author)
Yeager, Meredith (author)
Fraumeni, Joseph F (author)
Skryabin, Konstantin G (author)
McKay, James D (author)
Rothman, Nathaniel (author)
Chanock, Stephen J (author)
Lathrop, Mark (author)
Brennan, Paul (author)
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 (creator_code:org_t)
2010-12-05
2011
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:1, s. 60-65
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 × 10⁻¹⁴). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

density-lipoprotein hdl; kidney cancer; prostate-cancer; family-history; pancreatic-cancer; breast-cancer; risk; transcription; epidemiology; cholesterol

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Purdue, Mark P
Johansson, Matti ...
Zelenika, Diana
Toro, Jorge R
Scelo, Ghislaine
Moore, Lee E
show more...
Prokhortchouk, E ...
Wu, Xifeng
Kiemeney, Lamber ...
Gaborieau, Valer ...
Jacobs, Kevin B
Chow, Wong-Ho
Zaridze, David
Matveev, Vsevolo ...
Lubinski, Jan
Trubicka, Joanna
Szeszenia-Dabrow ...
Lissowska, Jolan ...
Rudnai, Péter
Fabianova, Eleon ...
Bucur, Alexandru
Bencko, Vladimir
Foretova, Lenka
Janout, Vladimir
Boffetta, Paolo
Colt, Joanne S
Davis, Faith G
Schwartz, Kendra ...
Banks, Rosamonde ...
Selby, Peter J
Harnden, Patrici ...
Berg, Christine ...
Hsing, Ann W
Grubb, Robert L
Boeing, Heiner
Vineis, Paolo
Clavel-Chapelon, ...
Palli, Domenico
Tumino, Rosario
Krogh, Vittorio
Panico, Salvator ...
Duell, Eric J
Quirós, José Ram ...
Sanchez, Maria-J ...
Navarro, Carmen
Ardanaz, Eva
Dorronsoro, Mire ...
Khaw, Kay-Tee
Allen, Naomi E
Bueno-de-Mesquit ...
Peeters, Petra H ...
Trichopoulos, Di ...
Linseisen, Jakob
Ljungberg, Börje
Overvad, Kim
Tjønneland, Anne
Romieu, Isabelle
Riboli, Elio
Mukeria, Anush
Shangina, Oxana
Stevens, Victori ...
Thun, Michael J
Diver, W Ryan
Gapstur, Susan M
Pharoah, Paul D
Easton, Douglas ...
Albanes, Demetri ...
Weinstein, Steph ...
Virtamo, Jarmo
Vatten, Lars
Hveem, Kristian
Njølstad, Inger
Tell, Grethe S
Stoltenberg, Cam ...
Kumar, Rajiv
Koppova, Kvetosl ...
Cussenot, Olivie ...
Benhamou, Simone
Oosterwijk, Egbe ...
Vermeulen, Sita ...
Aben, Katja K H
van der Marel, S ...
Ye, Yuanqing
Wood, Christophe ...
Pu, Xia
Mazur, Alexander ...
Boulygina, Eugen ...
Chekanov, Nikola ...
Foglio, Mario
Lechner, Doris
Gut, Ivo
Heath, Simon
Blanche, Hélène
Hutchinson, Amy
Thomas, Gilles
Wang, Zhaoming
Yeager, Meredith
Fraumeni, Joseph ...
Skryabin, Konsta ...
McKay, James D
Rothman, Nathani ...
Chanock, Stephen ...
Lathrop, Mark
Brennan, Paul
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Umeå University

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