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Temporal biomarker ...
Temporal biomarker profiling reveals longitudinal changes in risk of death or myocardial infarction in Non-ST-segment elevation acute coronary syndrome
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- Chan, Mark Y. (author)
- National University of Singapore
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- Neely, Megan L. (author)
- Duke Clinical Research Institute (DCRI)
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- Roe, Matthew T. (author)
- Duke University
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- Goodman, Shaun G. (author)
- Saint Michael's Hospital
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Cornel, Jan H. (author)
- Northwest Hospital Group, Alkmaar
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- Winters, Kenneth J. (author)
- Eli Lilly and Company
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- Jakubowski, Joseph A. (author)
- Eli Lilly and Company
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- Zhou, Chunmei (author)
- Eli Lilly and Company
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- Fox, Keith A. (author)
- University of Edinburgh
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- Armstrong, Paul W. (author)
- University of Alberta
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- White, Harvey D. (author)
- Auckland City Hospital
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- Prabhakaran, Dorairaj (author)
- Public Health Foundation of India
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- Ohman, E. Magnus (author)
- Duke University
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- Huber, Kurt (author)
- Sigmund Freud Private University
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(creator_code:org_t)
- 2017-07-01
- 2017
- English 13 s.
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In: Clinical Chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 63:7, s. 1214-1226
- Related links:
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http://dx.doi.org/10...
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Abstract
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- BACKGROUND: There are conflicting data on whether changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) concentrations between time points (delta NT-proBNP and hs-CRP) are associated with a change in prognosis. METHODS: We measured NT-proBNP and hs-CRP at 3 time points in 1665 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Cox proportional hazards was applied to the delta between temporal measurements to determine the continuous association with cardiovascular events. Effect estimates for delta NT-proBNP and hs-CRP are presented per 40% increase as the basic unit of temporal change. RESULTS: Median NT-proBNP was 370.0 (25th, 75th percentiles, 130.0, 996.0), 340.0 (135.0, 875.0), and 267.0 (111.0, 684.0) ng/L; and median hs-CRP was 4.6 (1.7, 13.1), 1.9 (0.8, 4.5), and 1.8 (0.8, 4.4) mg/L at baseline, 30 days, and 6 months, respectively. The deltas between baseline and 6 months were the most prognostically informative. Every 40% increase of delta NTproBNP (baseline to 6 months) was associated with a 14% greater risk of cardiovascular death (adjusted hazard ratio (HR) 1.14, 95% CI, 1.03-1.27) and with a 14% greater risk of all-cause death (adjusted HR 1.14, 95% CI, 1.04 -1.26), while every 40% increase of delta hs- CRP (baseline to 6 months) was associated with a 9% greater risk of the composite end point (adjusted HR 1.09, 95% CI, 1.02-1.17) and a 10% greater risk of myocardial infarction (adjusted HR 1.10, 95%, CI 1.00 -1.20). CONCLUSIONS: Temporal changes in NT-proBNP and hs-CRP are quantitatively associated with future cardiovascular events, supporting their role in dynamic risk stratification of NSTEACS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Chan, Mark Y.
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Neely, Megan L.
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Roe, Matthew T.
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Goodman, Shaun G ...
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Erlinge, David
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Cornel, Jan H.
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Winters, Kenneth ...
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Jakubowski, Jose ...
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Zhou, Chunmei
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Fox, Keith A.
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Armstrong, Paul ...
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White, Harvey D.
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Prabhakaran, Dor ...
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Ohman, E. Magnus
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Huber, Kurt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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Clinical Chemist ...
- By the university
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Lund University