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mTOR intersects ant...
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
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Sintes, J (author)
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Gentile, M (author)
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Zhang, SL (author)
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show more...
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Garcia-Carmona, Y (author)
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Magri, G (author)
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Cassis, L (author)
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Segura-Garzon, D (author)
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Ciociola, A (author)
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Grasset, EK (author)
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Bascones, S (author)
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Comerma, L (author)
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Pybus, M (author)
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Llige, D (author)
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Puga, I (author)
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Gutzeit, C (author)
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He, B (author)
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DuBois, W (author)
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Crespo, M (author)
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Pascual, J (author)
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Mensa, A (author)
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Arostegui, JI (author)
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Juan, M (author)
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Yague, J (author)
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Serrano, S (author)
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Lloreta, J (author)
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Meffre, E (author)
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Hahne, M (author)
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Cunningham-Rundles, C (author)
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Mock, BA (author)
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Cerutti, A (author)
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- 2017-11-13
- 2017
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 1462-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte subset that mounts antibody responses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). This receptor interacts with mTOR via the TLR adapter MyD88. The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through a rapamycin-sensitive pathway that integrates metabolic and antibody-inducing transcription programs, including NF-κB. Disruption of TACI–mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cell-conditional mTOR deficiency interrupts TACI signaling via NF-κB and cooperation with TLRs, thereby hampering IgG production to T-cell-independent antigens but not B-cell survival. Thus, mTOR drives innate-like antibody responses by linking proximal TACI signaling events with distal immunometabolic transcription programs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sintes, J
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Gentile, M
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Zhang, SL
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Garcia-Carmona, ...
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Magri, G
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Cassis, L
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show more...
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Segura-Garzon, D
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Ciociola, A
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Grasset, EK
-
Bascones, S
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Comerma, L
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Pybus, M
-
Llige, D
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Puga, I
-
Gutzeit, C
-
He, B
-
DuBois, W
-
Crespo, M
-
Pascual, J
-
Mensa, A
-
Arostegui, JI
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Juan, M
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Yague, J
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Serrano, S
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Lloreta, J
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Meffre, E
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Hahne, M
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Cunningham-Rundl ...
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Mock, BA
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Cerutti, A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet