Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

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Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

Accordini, S. (författare): Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy; Equal contribution as first authors,Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.

Calciano, L. (författare): Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy; Equal contribution as first authors,Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.

Johannessen, A. (författare): Centre for International Health, Dept of Global Public Health and Primary Care, University of Bergen, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.

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Benediktsdottir, B. (författare): Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, Reykjavik, Iceland.

Bertelsen, R. J. (författare): Dept of Clinical Science, University of Bergen, Bergen, Norway,Lung Clinic, Tartu University Hospital, Tartu, Estonia,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Oral Hlth Ctr Expertise Western Norway Vestland, Bergen, Norway.,Tartu Univ Hosp, Lung Clin, Tartu, Estonia.

Bråbäck, Lennart (författare): Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, Umeå, Sweden.

Dharmage, S. C. (författare): Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia,Centre for International Health, Dept of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Equal contribution as last authors,Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.

Forsberg, Bertil, professor, 1956- (författare): Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, Umeå, Sweden.

Real, F. G. (författare): Dept of Clinical Science, University of Bergen, Bergen, Norway; Dept of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway.

Holloway, J. W. (författare): Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom,Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England.

Holm, Mathias, 1969 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden.

Janson, Christer (författare): Uppsala universitet,Lung- allergi- och sömnforskning

Jogi, N. O. (författare): Dept of Clinical Science, University of Bergen, Bergen, Norway; Lung Clinic, Tartu University Hospital, Tartu, Estonia,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Tartu Univ Hosp, Lung Clin, Tartu, Estonia.

Jogi, R. (författare)

Malinovschi, Andrei, 1978- (författare): Uppsala universitet,Klinisk fysiologi

Marcon, A. (författare): Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy,Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.

Rovira, J. M. M. (författare): Servicio de Neumología, Complejo Hospitalario Universitario de Albacete (CHUA), Servicio de Salud de Castilla-La Mancha (SESCAM), Albacete, Spain,Complejo Hosp Univ Albacete CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain.

Sanchez-Ramos, J. L. (författare): Dept of Nursing, University of Huelva, Huelva, Spain,Univ Huelva, Dept Nursing, Huelva, Spain.

Schlunssen, V. (författare): Dept of Public Health, Aarhus University, Aarhus, Denmark,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.

Torén, Kjell, 1952 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden.

Jarvis, D. (författare): Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom; Equal contribution as last authors,Imperial Coll London, Fac Med, Natl Heart & Lung Inst, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.

Svanes, C. (författare)

Article,, Article, (författare)

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Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy; Equal contribution as first authors Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (creator_code:org_t)

2021-04-01
2021
Engelska.
Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 58:4

Relaterad länk:: https://erj.ersjourn...; visa fler...; https://doi.org/10.1...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very limited. We investigated multigeneration causal associations to estimate the causal effects of tobacco smoking on lung function within the paternal line. We analysed data from 383 adult offspring (age 18-47 years; 52.0% female) and their 274 fathers, who had participated in the European Community Respiratory Health Survey (ECRHS)/Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study and had provided valid measures of pre-bronchodilator lung function. Two counterfactual-based, multilevel mediation models were developed with: paternal grandmothers' smoking in pregnancy and fathers' smoking initiation in prepuberty as exposures; fathers' forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), or FEV1/FVC z-scores as potential mediators (proxies of unobserved biological mechanisms that are true mediators); and offspring's FEV1 and FVC, or FEV1/FVC z-scores as outcomes. All effects were summarised as differences (Delta) in expected z-scores related to fathers' and grandmothers' smoking history. Fathers' smoking initiation in prepuberty had a negative direct effect on both offspring's FEV1 (Delta z-score -0.36, 95% CI -0.63--0.10) and FVC (-0.50, 95% CI -0.80--0.20) compared with fathers' never smoking. Paternal grandmothers' smoking in pregnancy had a negative direct effect on fathers' FEV1/FVC -0.57, 95% CI -1.09--0.05) and a negative indirect effect on offspring's FEV1/FVC (-0.12, 95% CI -0.21--0.03) compared with grandmothers' not smoking before fathers' birth nor during fathers' childhood. Fathers' smoking in prepuberty and paternal grandmothers' smoking in pregnancy may cause lower lung function in offspring. Our results support the concept that lifestyle-related exposures during these susceptibility periods influence the health of future generations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

mediation analysis
nicotine exposure
epigenetic inheritance
cigarette-smoking
risk-factors
odds ratio
asthma
childhood
pregnancy
weight
Respiratory System

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Göteborgs universitet; Umeå universitet; Uppsala universitet

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