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Sökning: onr:"swepub:oai:DiVA.org:liu-191962" > Distinct translatom...

Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice

Kaczmarczyk, Lech (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,German Center for Neurodegenerative Diseases, Bonn, Germany,Wallenberg Center for Molecular Medicine
Schleif, Melvin (författare)
German Center for Neurodegenerative Diseases, Bonn, Germany
Dittrich, Lars (författare)
German Center for Neurodegenerative Diseases, Bonn, Germany
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Williams, Rhiannan H. (författare)
Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany
Koderman, Maruša (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Wallenberg Center for Molecular Medicine
Bansal, Vikas (författare)
Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Germany;German Center for Neurodegenerative Diseases, Tübingen, Germany
Rajput, Ashish (författare)
Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Germany; Maximon AG, Zug, Switzerland
Schulte, Theresa (författare)
German Center for Neurodegenerative Diseases, Bonn, Germany
Jonson, Maria (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Wallenberg Center for Molecular Medicine
Krost, Clemens (författare)
German Center for Neurodegenerative Diseases, Bonn, Germany
Testaquadra, Fabio J. (författare)
German Center for Neurodegenerative Diseases, Bonn, Germany
Bonn, Stefan (författare)
Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Germany
Jackson, Walker S. (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,German Center for Neurodegenerative Diseases, Bonn, Germany,Wallenberg Center for Molecular Medicine
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 (creator_code:org_t)
2022-08-12
2022
Engelska.
Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 18:8
Relaterad länk:
https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method in mice, translational responses of five neural subtypes to acquired prion disease (PrD) were measured. Pre-onset and disease onset timepoints were chosen based on longitudinal electroencephalography (EEG) that revealed a gradual increase in theta power between 10- and 18-weeks after prion injection, resembling a clinical feature of human PrD. At disease onset, marked by significantly increased theta power and histopathological lesions, mice had pronounced translatome changes in all five cell types despite appearing normal. Remarkably, at a pre-onset stage, prior to EEG and neuropathological changes, we found that 1) translatomes of astrocytes indicated reduced synthesis of ribosomal and mitochondrial components, 2) glutamatergic neurons showed increased expression of cytoskeletal genes, and 3) GABAergic neurons revealed reduced expression of circadian rhythm genes. These data demonstrate that early translatome responses to neurodegeneration emerge prior to conventional markers of disease and are cell type-specific. Therapeutic strategies may need to target multiple pathways in specific populations of cells, early in disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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