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Characterising the covariance pattern between lifestyle factors and structural brain measures : a multivariable replication study of two independent ageing cohorts
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- Demnitz, Naiara (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark
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- Hulme, Oliver J. (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark
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- Siebner, Hartwig R. (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark
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- (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
- In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 131, s. 115-123
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Magnetic resonance imaging (MRI)
- Modifiable lifestyle factors
- Old age
- White matter hyperintensities
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- ref (subject category)
- art (subject category)
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