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Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Christakoudi, Sofia (författare)
Imperial College London,King's College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Kings Coll London, MRC Ctr Transplantat, London, England.
Pagoni, Panagiota (författare)
University of Bristol,University of Ioannina,Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.;Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
Ferrari, Pietro (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
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Cross, Amanda J. (författare)
Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
Tzoulaki, Ioanna (författare)
Imperial College London,University of Ioannina,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
Muller, David C. (författare)
Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Freisling, Heinz (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Murphy, Neil (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Dossus, Laure (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Turzanski Fortner, Renee (författare)
German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
Agudo, Antonio (författare)
IDIBELL LHospitalet de Llobregat, Unit Nutr & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona, Spain.,Catalan Institute of Oncology
Overvad, Kim (författare)
Aarhus University,Aalborg University Hospital,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
Perez-Cornago, Aurora (författare)
University of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Key, Timothy J. (författare)
University of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Brennan, Paul (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Johansson, Mattias (författare)
International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
Tjønneland, Anne (författare)
Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.
Halkjær, Jytte (författare)
Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.
Boutron-Ruault, Marie Christine (författare)
University of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.
Artaud, Fanny (författare)
University of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.
Severi, Gianluca (författare)
University of Paris-Saclay,University of Florence,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.;Univ Florence, Dept Stat Comp Sci & Applicat G Parenti DISIA, Florence, Italy.
Kaaks, Rudolf (författare)
German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
Schulze, Matthias B. (författare)
German Institute of Human Nutrition,University of Potsdam,German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
Bergmann, Manuela M. (författare)
German Institute of Human Nutrition,German Inst Human Nutr Potsdam Rehbrucke DIfE, Dept Epidemiol, Nuthetal, Germany.
Masala, Giovanna (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO),ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Inst Canc Res Prevent & Clin Network, Florence, Italy.
Grioni, Sara (författare)
Istituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy.
Simeon, Vittorio (författare)
University of Campania Luigi Vanvitelli,Univ LVanvitelli, Dept Mental Phys Hlth & Prevent Med, Naples, Italy.
Tumino, Rosario (författare)
Provincial Health Authority (ASP) Ragusa,Prov Hlth Author ASP Ragusa, Canc Registry & Histopathol Dept, Ragusa, Italy.
Sacerdote, Carlotta (författare)
Citta' della Salute e della Scienza Hospital-University of Turin,Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.
Skeie, Guri (författare)
UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
Rylander, Charlotta (författare)
UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
Borch, Kristin Benjaminsen (författare)
UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
Quirós, J. Ramón (författare)
Publ Hlth Directorate, Asturias, Spain.
Rodriguez-Barranco, Miguel (författare)
CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),Escuela Andaluza Salud Publ EASP, Granada, Spain.;Inst Invest Biosanitaria ibs GRANADA, Granada, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
Chirlaque, Maria Dolores (författare)
CIBER Epidemiology and Public Health (CIBERESP),University of Murcia,Murcia Regional Health Council,Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.
Ardanaz, Eva (författare)
CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain.
Amiano, Pilar (författare)
Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;BioDonostia Researach Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain.
Drake, Isabel (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden.
Stocks, Tanja (författare)
Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
Häggström, Christel (författare)
Uppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Department of Surgical Science, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Dept Biobank Res, Umeå, Sweden.
Harlid, Sophia (författare)
Umeå universitet,Umeå University,Onkologi,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
Ellingjord-Dale, Merete (författare)
Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
Riboli, Elio (författare)
Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
Tsilidis, Konstantinos K. (författare)
Imperial College London,University of Ioannina,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
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 (creator_code:org_t)
2020-11-09
2021
Engelska.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 148:7, s. 1637-1651
Relaterad länk:
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (±0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

BMI change
cancer
middle adulthood
weight gain
weight loss
BMI change

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art (ämneskategori)
ref (ämneskategori)

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