The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

• Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

Ämnesord

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Nyckelord

Animals

Chagas Disease/drug therapy/parasitology

DNA Repair

DNA Replication

DNA; Mitochondrial/genetics

DNA; Protozoan/genetics

Genes; Protozoan

Genome; Protozoan

Humans

Meiosis

Membrane Proteins/chemistry/genetics/physiology

Multigene Family

Protozoan Proteins/chemistry/*genetics/physiology

Recombination; Genetic

Repetitive Sequences; Nucleic Acid

Research Support; N.I.H.; Extramural

Research Support; Non-U.S. Gov't

Research Support; U.S. Gov't; P.H.S.

Retroelements

Sequence Analysis; DNA

Signal Transduction

Telomere/genetics

Trypanocidal Agents/pharmacology/therapeutic use

Trypanosoma cruzi/chemistry/*genetics/physiology

Genetics

Genetik

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)