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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Orr, Nick (author)
Lemnrau, Alina (author)
Cooke, Rosie (author)
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Fletcher, Olivia (author)
Tomczyk, Katarzyna (author)
Jones, Michael (author)
Johnson, Nichola (author)
Lord, Christopher J. (author)
Mitsopoulos, Costas (author)
Zvelebil, Marketa (author)
McDade, Simon S. (author)
Buck, Gemma (author)
Blancher, Christine (author)
Trainer, Alison H. (author)
James, Paul A. (author)
Bojesen, Stig E. (author)
Bokmand, Susanne (author)
Nevanlinna, Heli (author)
Mattson, Johanna (author)
Friedman, Eitan (author)
Laitman, Yael (author)
Palli, Domenico (author)
Masala, Giovanna (author)
Zanna, Ines (author)
Ottini, Laura (author)
Giannini, Giuseppe (author)
Hollestelle, Antoinette (author)
van den Ouweland, Ans M. W. (author)
Novakovic, Srdjan (author)
Krajc, Mateja (author)
Gago-Dominguez, Manuela (author)
Castelao, Jose Esteban (author)
Olsson, Håkan (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Hedenfalk, Ingrid (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breast and Ovarian Cancer Genomics,Lund University Research Groups
Easton, Douglas F. (author)
Pharoah, Paul D. P. (author)
Dunning, Alison M. (author)
Bishop, D. Timothy (author)
Neuhausen, Susan L. (author)
Steele, Linda (author)
Houlston, Richard S. (author)
Garcia-Closas, Montserrat (author)
Ashworth, Alan (author)
Swerdlow, Anthony J. (author)
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 (creator_code:org_t)
2012-09-23
2012
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:11, s. 1182-1184
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

art (subject category)
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