Metabolic correlates of dopaminergic loss in dementia with lewy bodies

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Metabolic correlates of dopaminergic loss in dementia with lewy bodies

Huber, Maria (author): Ludwig Maximilians Univ Munchen, Germany

Beyer, Leonie (author): Ludwig Maximilians Univ Munchen, Germany

Prix, Catharina (author): Ludwig Maximilians Univ Munchen, Germany

Schoenecker, Sonja (author): Karolinska Institutet,Ludwig Maximilians Univ Munchen, Germany

Palleis, Carla (author): Ludwig Maximilians Univ Munchen, Germany

Rauchmann, Boris-Stephan (author): Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany

Morbelli, Silvia (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Chincarini, Andrea (author): Natl Inst Nucl Phys INFN, Italy

Bruffaerts, Rose (author): Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium

Vandenberghe, Rik (author): Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium

Van Laere, Koen (author): Univ Hosp Leuven, Belgium

Kramberger, Milica G. (author): Univ Med Ctr, Slovenia

Trost, Maja (author): Univ Med Ctr, Slovenia; Univ Med Ctr, Slovenia

Grmek, Marko (author): Univ Med Ctr, Slovenia

Garibotto, Valentina (author): Geneva Univ Hosp, Switzerland; Univ Geneva, Switzerland

Nicastro, Nicolas (author): Geneva Univ Hosp, Switzerland; Univ Cambridge, England

Frisoni, Giovanni B. (author): Geneva Univ Hosp, Switzerland

Lemstra, Afina W. (author): Vrije Univ Amsterdam Med Ctr, Netherlands

van der Zande, Jessica (author): Vrije Univ Amsterdam Med Ctr, Netherlands

Pilotto, Andrea (author): Univ Brescia, Italy; FERB ONLUS S Isidoro Hosp, Italy

Padovani, Alessandro (author): Univ Brescia, Italy

Garcia-Ptacek, Sara (author): Karolinska Inst, Sweden; Sadersjukhuset, Sweden

Savitcheva, Irina (author): Karolinska Univ Hosp, Sweden

Ochoa-Figueroa, Miguel A. (author): Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US,Region Östergötland, Medicinsk strålningsfysik

Davidsson, Anette, 1960- (author): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US

Camacho, Valle (author): Univ Autonoma Barcelona, Spain

Peira, Enrico (author): Natl Inst Nucl Phys INFN, Italy; Univ Genoa, Italy

Arnaldi, Dario (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Bauckneht, Matteo (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Pardini, Matteo (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Sambuceti, Gianmario (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Voeglein, Jonathan (author): Ludwig Maximilians Univ Munchen, Germany; DZNE German Ctr Neurodegenerat Dis, Germany

Schnabel, Jonas (author): Ludwig Maximilians Univ Munchen, Germany

Unterrainer, Marcus (author): Ludwig Maximilians Univ Munchen, Germany

Perneczky, Robert (author): Ludwig Maximilians Univ Munchen, Germany; DZNE German Ctr Neurodegenerat Dis, Germany; Imperial Coll, England

Pogarell, Oliver (author): Ludwig Maximilians Univ Munchen, Germany

Buerger, Katharina (author): DZNE German Ctr Neurodegenerat Dis, Germany

Catak, Cihan (author): University of Munich, Munich, Germany

Bartenstein, Peter (author): Ludwig Maximilians Univ Munchen, Germany

Cumming, Paul (author): University of Bern, Inselspital, Bern, Switzerland; Queensland University of Technology, Brisbane, Australia

Ewers, Michael (author): DZNE German Ctr Neurodegenerat Dis, Germany

Danek, Adrian (author): Ludwig Maximilians Univ Munchen, Germany

Levin, Johannes (author): Ludwig Maximilians Univ Munchen, Germany; DZNE German Ctr Neurodegenerat Dis, Germany

Aarsland, Dag (author): Karolinska Institutet,Stavanger University Hospital, Stavanger, Norway; King’s College London, London, United Kingdom

Nobili, Flavio (author): IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy

Rominger, Axel (author): Ludwig Maximilians Univ Munchen, Germany

Brendel, Matthias (author): Ludwig Maximilians Univ Munchen, Germany

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2019-12-16
2020
English.
In: Movement Disorders. - : WILEY. - 0885-3185 .- 1531-8257. ; 35, s. 595-605

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://onlinelibrar...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by I-123-Ioflupane brain single-photon emission computed tomography of dopamine transporter and F-18-fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill-understood. Objective We used the hitherto largest study cohort of combined imaging from the European consortium to elucidate the role of both biomarkers in the pathophysiological course of dementia with Lewy bodies. Methods We compared striatal dopamine deficiency and glucose metabolism of 84 dementia with Lewy body patients and comparable healthy controls. After normalization of data, we tested their correlation by region-of-interest-based and voxel-based methods, controlled for study center, age, sex, education, and current cognitive impairment. Metabolic connectivity was analyzed by inter-region coefficients stratified by dopamine deficiency and compared to healthy controls. Results There was an inverse relationship between striatal dopamine availability and relative glucose hypermetabolism, pronounced in the basal ganglia and in limbic regions. With increasing dopamine deficiency, metabolic connectivity showed strong deteriorations in distinct brain regions implicated in disease symptoms, with greatest disruptions in the basal ganglia and limbic system, coincident with the pattern of relative hypermetabolism. Conclusions Relative glucose hypermetabolism and disturbed metabolic connectivity of limbic and basal ganglia circuits are metabolic correlates of dopamine deficiency in dementia with Lewy bodies. Identification of specific metabolic network alterations in patients with early dopamine deficiency may serve as an additional supporting biomarker for timely diagnosis of dementia with Lewy bodies. (c) 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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By the author/editor: Huber, Maria; Beyer, Leonie; Prix, Catharina; Schoenecker, Son ...; Palleis, Carla; Rauchmann, Boris ...; show more...; Morbelli, Silvia; Chincarini, Andr ...; Bruffaerts, Rose; Vandenberghe, Ri ...; Van Laere, Koen; Kramberger, Mili ...; Trost, Maja; Grmek, Marko; Garibotto, Valen ...; Nicastro, Nicola ...; Frisoni, Giovann ...; Lemstra, Afina W ...; van der Zande, J ...; Pilotto, Andrea; Padovani, Alessa ...; Garcia-Ptacek, S ...; Savitcheva, Irin ...; Ochoa-Figueroa, ...; Davidsson, Anett ...; Camacho, Valle; Peira, Enrico; Arnaldi, Dario; Bauckneht, Matte ...; Pardini, Matteo; Sambuceti, Gianm ...; Voeglein, Jonath ...; Schnabel, Jonas; Unterrainer, Mar ...; Perneczky, Rober ...; Pogarell, Oliver; Buerger, Kathari ...; Catak, Cihan; Bartenstein, Pet ...; Cumming, Paul; Ewers, Michael; Danek, Adrian; Levin, Johannes; Aarsland, Dag; Nobili, Flavio; Rominger, Axel; Brendel, Matthia ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Movement Disorde ...

By the university: Linköping University; Karolinska Institutet

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Metabolic correlates of dopaminergic loss in dementia with lewy bodies

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