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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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- Wang, Z. (author)
- Icahn School of Medicine at Mount Sinai
-
- Emmerich, Andrew (author)
- Uppsala universitet,Molekylärbiologi
-
- Pillon, N. J. (author)
- Karolinska Institutet
- show more...
- Moore, T. (author)
- Hemerich, D. (author)
- Broos, S. (author)
- Ahluwalia, T. S. (author)
- Bartz, T. M. (author)
- Bielak, L. F. (author)
- Chong, M. (author)
- Chu, A. Y. (author)
- Berry, D. (author)
- Dorajoo, R. (author)
- Dueker, N. D. (author)
- Feenstra, B. (author)
- Feitosa, M. F. (author)
- Gieger, C. (author)
- Graff, M. (author)
- Haller, T. (author)
- Hartwig, F. P. (author)
- Hillis, D. A. (author)
- Huikari, V. (author)
- Heard-Costa, N. (author)
- Holzapfel, C. (author)
- Jackson, A. U. (author)
- Jorgensen, A. M. (author)
- Kaakinen, M. A. (author)
- Kerr, K. F. (author)
- Kim, B. (author)
- Koolhaas, C. M. (author)
- Kutalik, Z. (author)
- Lagou, V. (author)
- Lind, P. A. (author)
- Metzendorf, C. (author)
- Monroe, K. R. (author)
- Pacolet, A. (author)
- Perusse, L. (author)
- Pool, R. (author)
- Richmond, R. C. (author)
- Robiou-Du-Pont, S. (author)
- Schraut, K. E. (author)
- Schulz, C. A. (author)
- Tanaka, T. (author)
- Teumer, A. (author)
- Turman, C. (author)
- Van der Most, P. J. (author)
- Vanmunster, M. (author)
- Van Rooij, F. J. A. (author)
- Van Vliet-Ostaptchouk, J. V. (author)
- Zhang, X. S. (author)
- Zhao, J. H. (author)
- Zhao, W. (author)
- Balkhiyarova, Z. (author)
- Balslev-Harder, M. N. (author)
- Beilby, J. (author)
- Blangero, J. (author)
- Boomsma, D. I. (author)
- Brage, S. (author)
- Braund, P. S. (author)
- Brody, J. A. (author)
- Bruinenberg, M. (author)
- Ekelund, U. (author)
- Liu, C. T. (author)
- Cole, J. W. (author)
- Collins, F. S. (author)
- Cupples, L. A. (author)
- Esko, T. (author)
- Faul, J. D. (author)
- Fernandez-Rhodes, L. (author)
- Fohner, A. E. (author)
- Franco, O. H. (author)
- Galesloot, T. E. (author)
- Gordon, S. D. (author)
- Grarup, N. (author)
- Hartman, C. A. (author)
- Heiss, G. (author)
- Hui, J. (author)
- Illig, T. (author)
- James, A. (author)
- Joshi, P. K. (author)
- Jung, T. (author)
- Kahonen, M. (author)
- Kilpelainen, T. O. (author)
- Koh, W. P. (author)
- Kolcic, I. (author)
- Kraft, P. P. (author)
- Kuusisto, J. (author)
- Launer, L. J. (author)
- Li, A. H. (author)
- Linneberg, A. (author)
- Luan, J. A. (author)
- Vidal, P. M. (author)
- Medland, S. E. (author)
- Milaneschi, Y. (author)
- Moscati, A. (author)
- Musk, B. (author)
- Nelson, C. P. (author)
- Nolte, I. M. (author)
- Pedersen, N. L. (author)
- Peters, A. (author)
- Peyser, P. A. (author)
- Power, C. (author)
- Raitakari, O. T. (author)
- Reedik, M. (author)
- Reiner, A. P. (author)
- Ridker, P. M. (author)
- Rudan, I. (author)
- Ryan, K. (author)
- Sarzynski, M. A. (author)
- Scott, L. J. (author)
- Scott, R. A. (author)
- Sidney, S. (author)
- Siggeirsdottir, K. (author)
- Smith, A. V. (author)
- Smith, J. A. (author)
- Sonestedt, E. (author)
- Strom, M. (author)
- Tai, E. S. (author)
- Teo, K. K. (author)
- Thorand, B. (author)
- Tonjes, A. (author)
- Tremblay, A. (author)
- Uitterlinden, A. G. (author)
- Vangipurapu, J. (author)
- Van Schoor, N. (author)
- Volker, U. (author)
- Willemsen, G. (author)
- Williams, K. (author)
- Wong, Q. (author)
- Xu, H. C. (author)
- Young, K. L. (author)
- Yuan, J. M. (author)
- Zillikens, M. C. (author)
- Zonderman, A. B. (author)
- Ameur, A. (author)
- Bandinelli, S. (author)
- Bis, J. C. (author)
- Boehnke, M. (author)
- Bouchard, C. (author)
- Chasman, D. I. (author)
- Smith, G. D. (author)
- De Geus, E. J. C. (author)
- Deldicque, L. (author)
- Dorr, M. (author)
- Evans, M. K. (author)
- Ferrucci, L. (author)
- Fornage, M. (author)
- Fox, C. (author)
- Garland, T. (author)
- Gudnason, V. (author)
- Hansen, T. (author)
- Hayward, C. (author)
- Horta, B. L. (author)
- Hypponen, E. (author)
- Jarvelin, M. R. (author)
- Johnson, W. C. (author)
- Kardia, S. L. R. (author)
- Kiemeney, L. A. (author)
- Laakso, M. (author)
- Langenberg, C. (author)
- Lehtimaki, T. (author)
- Le Marchand, L. (author)
- Magnusson, P. K. E. (author)
- Martin, N. G. (author)
- Melbye, M. (author)
- Metspalu, A. (author)
- Meyre, D. (author)
- North, K. E. (author)
- Oldehinkel, A. J. (author)
- Orho-Melander, M. (author)
- Pare, G. (author)
- Park, T. (author)
- Pedersen, O. (author)
- Penninx, Bwjh (author)
- Pers, T. H. (author)
- Polasek, O. (author)
- Prokopenko, I. (author)
- Rotimi, C. N. (author)
- Samani, N. J. (author)
- Sim, X. (author)
- Snieder, H. (author)
- Sorensen, T. I. A. (author)
- Spector, T. D. (author)
- Timpson, N. J. (author)
- Van Dam, R. M. (author)
- Van der Velde, N. (author)
- Van Duijn, C. M. (author)
- Vollenweider, P. (author)
- Volzke, H. (author)
- Voortman, T. (author)
- Waeber, G. (author)
- Wareham, N. J. (author)
- Weir, D. R. (author)
- Wichmann, H. E. (author)
- Wilson, J. F. (author)
- Hevener, A. L. (author)
- Krook, A. (author)
- Zierath, J. R. (author)
- Thomis, M. A. I. (author)
- Loos, R. J. F. (author)
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- (creator_code:org_t)
- 2022-09-07
- 2022
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 54:9
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- apolipoprotein-e genotype
- ld score regression
- gene-expression
- exercise
- complex
- performance
- gwas
- heritability
- mortality
- fitness
- Genetics & Heredity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Pillon, N. J.
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