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Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
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Toenjes, Anke (författare)
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Koriath, Moritz (författare)
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Schleinitz, Dorit (författare)
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visa fler...
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Dietrich, Kerstin (författare)
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Boettcher, Yvonne (författare)
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Rayner, Nigel W. (författare)
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- Almgren, Peter (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Enigk, Beate (författare)
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Richter, Olaf (författare)
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Rohm, Silvio (författare)
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Fischer-Rosinsky, Antje (författare)
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Pfeiffer, Andreas (författare)
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Hoffmann, Katrin (författare)
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Krohn, Knut (författare)
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Aust, Gabriela (författare)
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Spranger, Joachim (författare)
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Blueher, Matthias (författare)
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Kovacs, Peter (författare)
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Stumvoll, Michael (författare)
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(creator_code:org_t)
- 2009-09-03
- 2009
- Engelska.
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 18:23, s. 4662-4668
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (similar to 390 000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Toenjes, Anke
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Koriath, Moritz
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Schleinitz, Dori ...
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Dietrich, Kersti ...
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Boettcher, Yvonn ...
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Rayner, Nigel W.
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visa fler...
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Almgren, Peter
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Enigk, Beate
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Richter, Olaf
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Rohm, Silvio
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Fischer-Rosinsky ...
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Pfeiffer, Andrea ...
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Hoffmann, Katrin
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Krohn, Knut
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Aust, Gabriela
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Spranger, Joachi ...
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Groop, Leif
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Blueher, Matthia ...
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Kovacs, Peter
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Stumvoll, Michae ...
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