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Unexpected short- a...
Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior
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- Farinha-Ferreira, Miguel (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Rei, Nadia (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.;Univ NOVA Lisboa, Fac Ciencias Med, Chron Dis Res Ctr, NOVA Med Sch,Computat & Expt Biol Grp, Campo Martires Patria 130, P-1169056 Lisbon, Portugal.
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- Fonseca-Gomes, Joao (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Miranda-Lourenco, Catarina (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Serrao, Paula (författare)
- Univ Porto, Fac Med, Dept Biomed, Unidade Farmacol & Terapeut, P-4200319 Porto, Portugal.;Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, P-4200319 Porto, Portugal.
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- Vaz, Sandra H. (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Gomes, Joana I. (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Martins, Valeria (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Pereira, Beatriz (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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- Sebastiao, Ana M. (författare)
- Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.
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Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal. Univ Lisbon, Fac Med, Inst Farmacol & Neurociencias, P-1649028 Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, P-1649028 Lisbon, Portugal.;Univ NOVA Lisboa, Fac Ciencias Med, Chron Dis Res Ctr, NOVA Med Sch,Computat & Expt Biol Grp, Campo Martires Patria 130, P-1169056 Lisbon, Portugal. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Neuropharmacology. - : Elsevier. - 0028-3908 .- 1873-7064. ; 214
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Chronic adolescent cannabinoid receptor agonist exposure has been shown to lead to persistent increases in depressive-like behaviors. This has been a key obstacle to the development of cannabinoid-based therapeutics. However, most of the published work has been performed with only three compounds, namely & UDelta;9-tetrahydro-cannabinol, CP55,940 and WIN55,212-2. Hypothesizing that different compounds may lead to distinct out-comes, we herein used the highly potent CB1R/CB2R full agonist HU-210, and first aimed at replicating cannabinoid-induced long-lasting effects, by exposing adolescent female Sprague-Dawley rats to increasing doses of HU-210, for 11 days and testing them at adulthood, after a 30-day drug washout. Surprisingly, HU-210 did not significantly impact adult anxious-or depressive-like behaviors. We then tested whether chronic adolescent HU -210 treatment resulted in short-term (24h) alterations in depressive-like behavior. Remarkably, HU-210 treat-ment simultaneously induced marked antidepressant-and prodepressant-like responses, in the modified forced swim (mFST) and sucrose preference tests (SPT), respectively. Hypothesizing that mFST results were a misleading artifact of HU-210-induced behavioral hyperreactivity to stress, we assessed plasmatic noradrenaline and corticosterone levels, under basal conditions and following an acute swim-stress episode. Notably, we found that while HU-210 did not alter basal noradrenaline or corticosterone levels, it greatly augmented the stress-induced increase in both. Our results show that, contrary to previously studied cannabinoid receptor agonists, HU-210 does not induce persisting depressive-like alterations, despite inducing marked short-term increases in stress-induced reactivity. By showing that not all cannabinoid receptor agonists may induce long-term negative effects, these results hold significant relevance for the development of cannabinoid-based therapeutics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- HU-210
- Adolescence
- Depression
- Anxiety
- Cannabinoids
- Stress
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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