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Effects of Peroral ...
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study
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Tofiq, A. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Basun, H. (författare)
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Cederholm, T. (författare)
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Eriksdotter, M. (författare)
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Faxen-Irving, G. (författare)
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Hjorth, E. (författare)
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Jerneren, F. (författare)
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Schultzberg, M. (författare)
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Wahlund, L. O. (författare)
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Palmblad, J. (författare)
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Freund-Levi, Y. (författare)
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- Engelska.
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Ingår i: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 83:3, s. 1291-1301
- Relaterad länk:
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https://discovery.uc...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Studies have suggested a connection between a decrease in the levels of polyunsaturated fatty acids (PUFAs) and Alzheimer's disease (AD). We aimed to assess the effect of supplementation with omega-3 fatty acids (n-3 FAs) on biomarkers analyzed in the cerebrospinal fluid (CSF) of patients diagnosed with AD. Objective: To investigate the effects of daily supplementation with 2.3 g of PUFAs in AD patients on the biomarkers in CSF described below. We also explored the possible correlation between these biomarkers and the performance in the cognitive test Mini-Mental State Examination (MMSE). Methods: Thirty-three patients diagnosed with AD were randomized to either treatment with a daily intake of 2.3 g of n-3 FAs (n = 18) or placebo (n = 15). CSF samples were collected at baseline and after six months of treatment, and the following biomarkers were analyzed: A beta 38, A beta 40, A beta 42, t-tau, p-tau, neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), soluble IL-1 receptor type II (sIL-1RII), and IL-6. Results: There were no significant differences between the groups concerning the level of the different biomarkers in the CSF at baseline. Within the treatment group, there was a small but significant increase in both YKL-40 (p = 0.04) and NfL (p = 0.03), while the other CSF biomarkers remained stable. Conclusion: Supplementation with n-3 FAs had a statistically significant effect on NfL and YKL-40, resulting in an increase of both biomarkers, indicating a possible increase of inflammatory response and axonal damage. This increase in biomarkers did not correlate with MMSE score.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Chitinase-3-like protein 1
- dementia
- inflammation
- mini-mental state
- examination
- neurodegeneration
- neurofilament light
- YKL-40
- docosahexaenoic acid
- amyloid-beta
- butyrylcholinesterase activity
- ii
- receptor
- dementia
- interleukin-6
- acetylcholinesterase
- markers
- cells
- tau
- Neurosciences & Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tofiq, A.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Basun, H.
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Cederholm, T.
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Eriksdotter, M.
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visa fler...
-
Faxen-Irving, G.
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Hjorth, E.
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Jerneren, F.
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Schultzberg, M.
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Wahlund, L. O.
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Palmblad, J.
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Freund-Levi, Y.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Journal of Alzhe ...
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Göteborgs universitet