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Discovery and valid...
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
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- Shi, Liu (author)
- Department of Psychiatry, University of Oxford, Oxford, United Kingdom
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Westwood, Sarah (author)
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Baird, Alison L (author)
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Winchester, Laura (author)
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Dobricic, Valerija (author)
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Kilpert, Fabian (author)
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Hong, Shengjun (author)
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Franke, Andre (author)
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Hye, Abdul (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Morgan, Angharad R (author)
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Bos, Isabelle (author)
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Vos, Stephanie J B (author)
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Buckley, Noel J (author)
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Kate, Mara Ten (author)
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Scheltens, Philip (author)
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Vandenberghe, Rik (author)
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Gabel, Silvy (author)
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Meersmans, Karen (author)
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Engelborghs, Sebastiaan (author)
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De Roeck, Ellen E (author)
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Sleegers, Kristel (author)
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Frisoni, Giovanni B (author)
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Blin, Olivier (author)
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Richardson, Jill C (author)
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Bordet, Régis (author)
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Molinuevo, José L (author)
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Rami, Lorena (author)
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Kettunen, Petronella (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Tsolaki, Magda (author)
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Verhey, Frans (author)
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Lleó, Alberto (author)
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Alcolea, Daniel (author)
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- Popp, Julius (author)
- Karolinska Institutet
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Peyratout, Gwendoline (author)
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Martinez-Lage, Pablo (author)
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Tainta, Mikel (author)
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Johannsen, Peter (author)
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Teunissen, Charlotte E (author)
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- Freund-Levi, Yvonne, 1956- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Psychiatry in Region Örebro County and School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom
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Frölich, Lutz (author)
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Legido-Quigley, Cristina (author)
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Barkhof, Frederik (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Baker, Susan (author)
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Morgan, B Paul (author)
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Streffer, Johannes (author)
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Visser, Pieter Jelle (author)
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Bertram, Lars (author)
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Lovestone, Simon (author)
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- Nevado-Holgado, Alejo J (author)
- Department of Psychiatry, University of Oxford, Oxford, United Kingdom
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(creator_code:org_t)
- 2019-09-05
- 2019
- English.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279 .- 1552-5260. ; 15:11, s. 1478-1488
- Related links:
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https://onlinelibrar...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve = 0.78) and the replication group (area under the curve = 0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization.The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyloid beta
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Shi, Liu
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Westwood, Sarah
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Baird, Alison L
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Winchester, Laur ...
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Dobricic, Valeri ...
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Kilpert, Fabian
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show more...
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Hong, Shengjun
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Franke, Andre
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Hye, Abdul
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Ashton, Nicholas ...
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Morgan, Angharad ...
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Bos, Isabelle
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Vos, Stephanie J ...
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Buckley, Noel J
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Kate, Mara Ten
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Scheltens, Phili ...
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Vandenberghe, Ri ...
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Gabel, Silvy
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Meersmans, Karen
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Engelborghs, Seb ...
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De Roeck, Ellen ...
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Sleegers, Kriste ...
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Frisoni, Giovann ...
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Blin, Olivier
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Richardson, Jill ...
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Bordet, Régis
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Molinuevo, José ...
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Rami, Lorena
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Wallin, Anders, ...
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Lleó, Alberto
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Alcolea, Daniel
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Popp, Julius
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Peyratout, Gwend ...
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Martinez-Lage, P ...
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Tainta, Mikel
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Johannsen, Peter
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Teunissen, Charl ...
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Legido-Quigley, ...
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Barkhof, Frederi ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Baker, Susan
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Morgan, B Paul
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Streffer, Johann ...
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Visser, Pieter J ...
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Bertram, Lars
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Lovestone, Simon
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Nevado-Holgado, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's & de ...
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Alzheimer's & De ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet