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Heritability of cou...
Heritability of cough across two generations : the RHINESSA study.
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- Emilsson, Össur Ingi (author)
- Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Johansson, Henrik (author)
- Department of Women’s and Children’s Health, Physiotherapy, Uppsala University, Uppsala, Sweden
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- Johannessen, Ane (author)
- Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
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- Janson, Christer (author)
- Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Palm, Andreas (author)
- Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Franklin, Karl A. (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Oudin, Anna (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Gómez Real, Francisco (author)
- Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
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- Holm, Mathias (author)
- Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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- Gislason, Thorarinn (author)
- Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Landspitali University Hospital, Department of Sleep, Reykjavik, Iceland
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- Lindberg, Eva (author)
- Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Jõgi, Rain (author)
- The Lung Clinic, Tartu University Hospital, Tartu, Estonia
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- Schlünssen, Vivi (author)
- Department of Public Health, Research unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
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- Callejas-González, Francisco Javier (author)
- Servicio De Neumología, Complejo Hospitalario Universitario De Albacete, Albacete, Spain
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- Zhang, Jingwen (author)
- Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Integrativ Fysiologi,Klinisk fysiologi,Lung- allergi- och sömnforskning,Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden
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- Svanes, Cecilie (author)
- Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
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- Ekström, Magnus (author)
- Department of Respiratory Medicine, Allergology and Palliative Medicine, Institution for Clinical Sciences, Lund University, Lund, Sweden
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(creator_code:org_t)
- European Respiratory Society, 2024
- 2024
- English.
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In: ERJ open research. - : European Respiratory Society. - 2312-0541. ; 10:4
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Lungmedicin
- Lung Medicine
- Clinical Physiology
- Klinisk fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Emilsson, Össur ...
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Johansson, Henri ...
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Johannessen, Ane
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Janson, Christer
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Palm, Andreas
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Franklin, Karl A ...
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Oudin, Anna
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Gómez Real, Fran ...
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Holm, Mathias
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Gislason, Thorar ...
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Lindberg, Eva
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Jõgi, Rain
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Schlünssen, Vivi
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Callejas-Gonzále ...
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Zhang, Jingwen
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Malinovschi, And ...
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Svanes, Cecilie
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Ekström, Magnus
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ERJ open researc ...
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Uppsala University
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Umeå University