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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Johannesson, Magnus (author)
Stockholm School of Economics,Handelshögskolan i Stockholm
Power, Robert A. (author)
deCODE Genetics,VU University (NL)
Steinberg, Stacy (author)
deCODE Genetics
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Bjornsdottir, Gyda (author)
deCODE Genetics
Rietveld, Cornelius A. (author)
Erasmus University (NL)
Abdellaoui, Abdel (author)
VU University (NL),Erasmus University (NL),Radboud University (NL)
Nivard, Michel M. (author)
VU University (NL)
Galesloot, Tessel E. (author)
Radboud University (NL)
Hottenga, Jouke-Jan (author)
VU University (NL)
Willemsen, Gonneke (author)
VU University (NL)
Cesarini, David (author)
Center for Experimental Social Science
Benjamin, Daniel J. (author)
Cornell University (US)
Magnusson, Patrik K. E. (author)
Karolinska Institutet,Karolinska Institutet (SE)
Ullén, Fredrik (author)
Karolinska Institutet,Karolinska Institutet (SE)
Tiemeier, Henning (author)
Erasmus University (NL)
Hofman, Albert (author)
Erasmus University (NL)
Van Rooij, Frank J A (author)
Erasmus University (NL)
Walters, Bragi (author)
deCODE Genetics
Sigurdsson, Engilbert (author)
University of Iceland
Thorgeirsson, Thorgeir E. (author)
deCODE Genetics
Ingason, Andres (author)
deCODE Genetics
Helgason, Agnar (author)
deCODE Genetics
Kong, Augustine (author)
University of Iceland
Kiemeney, Lambertus A (author)
Radboud University (NL)
Koellinger, Philipp D. (author)
Erasmus School of Economics (NL)
Boomsma, Dorret I. (author)
VU University (NL)
Gudbjartsson, Daniel (author)
deCODE Genetics
Stefansson, Kari (author)
deCODE Genetics
Stefansson, Hreinn (author)
deCODE Genetics
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 (creator_code:org_t)
2015-06-08
2015
English.
In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 18:7, s. 953-
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

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