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Impact of body mass...
Impact of body mass index on the five-year outcome of patients having percutaneous coronary interventions with drug-eluting stents
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- Sarno, Giovanna (author)
- Department of Interventional Cardiology, Erasmus MC, Rotterdam, Netherlands
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Räber, Lorenz (author)
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Onuma, Yoshinobu (author)
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Garg, Scot (author)
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Brugaletta, Salvatore (author)
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van Domburg, Ron T (author)
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Pilgrim, Thomas (author)
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Pfäffli, Nico (author)
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Wenaweser, Peter (author)
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Windecker, Stephan (author)
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Serruys, Patrick (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 108:2, s. 195-201
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The purpose of this study was to assess the impact of body mass index (BMI) on clinical outcome of patients treated by percutaneous coronary intervention (PCI) using drug-eluting stents. Patients were stratified according to BMI as normal (<25 kg/m2), overweight (25 to 30 kg/m2), or obese (>30 kg/m2). At 5-year follow-up all-cause death, myocardial infarction, clinically justified target vessel revascularization (TVR), and definite stent thrombosis were assessed. A complete dataset was available in 7,427 patients, of which 45%, 22%, and 33% were classified according to BMI as overweight, obese, and normal, respectively. Mean age of patients was significantly older in those with a normal BMI (p <0.05). Incidence of diabetes mellitus, hypertension, and dyslipidemia increased as BMI increased (p <0.05). Significantly higher rates of TVR (15.3% vs 12.8%, p = 0.02) and early stent thrombosis (1.5% vs 0.9%, p = 0.04) were observed in the obese compared to the normal BMI group. No significant difference among the 3 BMI groups was observed for the composite of death/myocardial infarction/TVR or for definite stent thrombosis at 5 years, whereas the normal BMI group was at higher risk for all-cause death at 5 years (obese vs normal BMI, hazard ratio 0.74, confidence interval 0.53 to 0.99, p = 0.05; overweight vs normal BMI, hazard ratio 0.73, confidence interval 0.59 to 0.94, p = 0.01) in the multivariate Cox proportional hazard model. Age resulted in a linearly dependent covariate with BMI in the all-cause 5-year mortality multivariate model (p = 0.001). In conclusion, the “obesity paradox” observed in 5-year all-cause mortality could be explained by the higher rate of elderly patients in the normal BMI group and the existence of colinearity between BMI and age. However, obese patients had a higher rate of TVR and early stent thrombosis and a higher rate of other risk factors such as diabetes mellitus, hypertension, and hypercholesterolemia.
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- art (subject category)
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- By the author/editor
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Sarno, Giovanna
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Räber, Lorenz
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Onuma, Yoshinobu
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Garg, Scot
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Brugaletta, Salv ...
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van Domburg, Ron ...
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show more...
-
Pilgrim, Thomas
-
Pfäffli, Nico
-
Wenaweser, Peter
-
Windecker, Steph ...
-
Serruys, Patrick
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show less...
- Articles in the publication
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American Journal ...
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Uppsala University