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The genomics of heart failure: design and rationale of the HERMES consortium

Lumbers, R. T. (author)
Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;BHF Research Accelerator University College London London UK
Shah, S. (author)
Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia;Institute of Cardiovascular Science University College London London UK,Division of Molecular and Clinical Medicine University of Dundee, Ninewells Hospital and Medical School Dundee UK
Lin, H. H. (author)
Section of Computational Biomedicine, Department of Medicine Boston University School of Medicine Boston MA USA;National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK,Division of Cardiology, Department of Medicine Emory University Medical Center Atlanta GA USA
show more...
Czuba, Tomasz (author)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Henry, A. (author)
Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Institute of Cardiovascular Science University College London London UK
Swerdlow, D. I. (author)
Institute of Cardiovascular Science University College London London UK;Department of Medicine Imperial College London London UK
Malarstig, A. (author)
Karolinska Institute,Pfizer Inc. US
Andersson, C. (author)
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA;Department of Cardiology Herlev Gentofte Hospital Herlev Denmark
Verweij, N. (author)
Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands
Holmes, M. V. (author)
Medical Research Council Population Health Research Unit at the University of Oxford Oxford UK;Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute University of Oxford Oxford UK;National Institute for Health Research Oxford Biomedical Research Centre Oxford University Hospital Oxford UK,Oxford University Hospitals NHS Foundation Trust
Ärnlöv, Johan, 1970- (author)
Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Stockholm
Svensson, P. (author)
Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
Hemingway, H. (author)
Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.
Sallah, N. (author)
Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;UCL Genetics Institute University College London London UK
Almgren, Peter (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Aragam, K. G. (author)
Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Center for Genomic Medicine Massachusetts General Hospital Boston MA USA;Cardiovascular Research Center Massachusetts General Hospital Boston MA USA
Asselin, G. (author)
Montreal Heart Institute Montreal Quebec Canada
Backman, J. D. (author)
Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.
Lind, Lars (author)
Uppsala universitet,Klinisk epidemiologi,Washington University School of Medicine
Bloom, H. L. (author)
Boersma, E. (author)
Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands
Brandimarto, J. (author)
Penn Cardiovascular Institute, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Brown, M. R. (author)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center at Houston Houston TX USA
Brunner-La Rocca, H. P. (author)
Maastricht University Medical Center Maastricht The Netherlands,Yukioka Hospital
Carey, D. J. (author)
Department of Molecular and Functional Genomics Geisinger Danville PA USA,Geisinger Health System
Chaffin, M. D. (author)
Cardiovascular Disease Initiative The Broad Institute of MIT and Harvard Cambridge MA USA,Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald
Chasman, D. I. (author)
Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA;Harvard Medical School Boston MA USA
Chazara, O. (author)
Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D AstraZeneca Cambridge UK
Chen, X. (author)
Karolinska Institute
Chen, X. (author)
Chung, J. H. (author)
Chutkow, W. (author)
Novartis Institutes for Biomedical Research Cambridge MA USA,Novartis Institutes for BioMedical Research, Inc.
Cleland, J. G. F. (author)
Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK;National Heart and Lung Institute Imperial College London UK,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK,Translational and Clinical Research Servier Cardiovascular Center for Therapeutic Innovation Suresnes France
Cook, J. P. (author)
Department of Biostatistics University of Liverpool Liverpool UK
de Denus, S. (author)
Montreal Heart Institute Montreal Quebec Canada;Faculty of Pharmacy Université de Montréal Montreal Quebec Canada
Dehghan, A. (author)
Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK;MRC‐PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK
Engström, Gunnar (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Denaxas, S. (author)
Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK;The Alan Turing Institute, British Library London UK
Doney, A. S. (author)
Dorr, M. (author)
Dudley, S. C. (author)
Cardiovascular Division, Department of Medicine University of Minnesota Minneapolis MN USA
Engstrom, G. (author)
Esko, T. (author)
Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Estonian Genome Center, Institute of Genomics University of Tartu Tartu Estonia
Fatemifar, G. (author)
Felix, S. B. (author)
Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald
Finan, C. (author)
Institute of Cardiovascular Science University College London London UK
Ford, I. (author)
Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK
Fougerousse, F. (author)
Fouodjio, R. (author)
Montreal Heart Institute Montreal Quebec Canada
Ghanbari, M. (author)
Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands
Ghasemi, S. (author)
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik
Giulianini, F. (author)
Gottdiener, J. S. (author)
Gross, S. (author)
Gudbjartsson, D. F. (author)
Gui, H. S. (author)
Gutmann, R. (author)
Haggerty, C. M. (author)
van der Harst, P. (author)
Helgadottir, A. (author)
Hillege, H. (author)
Hyde, C. L. (author)
Smith, J. Gustav, 1982 (author)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
Jukema, J. W. (author)
Kamanu, F. (author)
Kardys, I. (author)
Kavousi, M. (author)
Khaw, K. T. (author)
Kleber, M. E. (author)
Kober, L. (author)
Koekemoer, A. (author)
Karolinska Institutet
Kraus, B. (author)
Kuchenbaecker, K. (author)
Langenberg, C. (author)
Lind, L. (author)
Lindgren, C. M. (author)
Broad Institute,University of Oxford,Wellcome Trust Centre for Human Genetics
London, B. (author)
Lotta, L. A. (author)
Lovering, R. C. (author)
Luan, J. A. (author)
Magnusson, P. (author)
Mahajan, A. (author)
Mann, D. (author)
Margulies, K. B. (author)
Marston, N. A. (author)
Marz, W. (author)
McMurray, J. J. V. (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
Melloni, G. (author)
Mordi, I. R. (author)
Perola, Markus (author)
Finnish National Institute for Health and Welfare
Morris, A. D. (author)
Morris, A. P. (author)
Morrison, A. C. (author)
Nagle, M. W. (author)
Nelson, C. P. (author)
Newton-Cheh, C. (author)
Niessner, A. (author)
Niiranen, T. (author)
Nowak, C. (author)
Karolinska Institutet
O'Donoghue, M. L. (author)
Owens, A. T. (author)
Palmer, C. N. A. (author)
Pare, G. (author)
Perola, M. (author)
Perreault, L. P. L. (author)
Portilla-Fernandez, E. (author)
Psaty, B. M. (author)
Rice, K. M. (author)
Ridker, P. M. (author)
Romaine, S. P. R. (author)
Roselli, C. (author)
Rotter, J. I. (author)
Ruff, C. T. (author)
Sabatine, M. S. (author)
Salo, P. (author)
Salomaa, V. (author)
van Setten, J. (author)
Shalaby, A. A. (author)
Smelser, D. T. (author)
Smith, N. L. (author)
Stefansson, K. (author)
Stender, S. (author)
Stott, D. J. (author)
Sveinbjornsson, G. (author)
Tammesoo, M. L. (author)
Tardif, J. C. (author)
Taylor, K. D. (author)
Teder-Laving, M. (author)
Teumer, A. (author)
Thorgeirsson, G. (author)
Thorsteinsdottir, U. (author)
Torp-Pedersen, C. (author)
Trompet, S. (author)
Tuckwell, D. (author)
Tyl, B. (author)
Uitterlinden, A. G. (author)
Vaura, F. (author)
Veluchamy, A. (author)
Visscher, P. M. (author)
Volker, U. (author)
Voors, A. A. (author)
Wang, X. S. (author)
Wareham, N. J. (author)
Weeke, P. E. (author)
Weiss, R. (author)
White, H. D. (author)
Wiggins, K. L. (author)
Xing, H. M. (author)
Yang, J. (author)
Yang, Y. F. (author)
Yerges-Armstrong, L. M. (author)
Yu, B. (author)
Zannad, F. (author)
Zhao, F. Y. (author)
Wilk, J. B. (author)
Holm, H. (author)
Sattar, N. (author)
Lubitz, S. A. (author)
Lanfear, D. E. (author)
Shah, S. (author)
Dunn, M. E. (author)
Wells, Q. S. (author)
Asselbergs, F. W. (author)
Hingorani, A. D. (author)
Dube, M. P. (author)
Samani, N. J. (author)
Lang, C. C. (author)
Cappola, T. P. (author)
Ellinor, P. T. (author)
Vasan, R. S. (author)
Smith, J. Gustav, 1982 (author)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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 (creator_code:org_t)
 
2021-09-03
2021
English.
In: Esc Heart Failure. - : Wiley. - 2055-5822. ; 8:6, s. 5531-5541
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Heart failure
Cardiomyopathy
Genetics
Biomarkers
Association studies
wide association
african ancestry
aging research
epidemiology
metaanalysis
classification
replication
cohorts
adults
risk
Cardiovascular System & Cardiology
Heart failure

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Lumbers, R. T.
Shah, S.
Lin, H. H.
Czuba, Tomasz
Henry, A.
Swerdlow, D. I.
show more...
Malarstig, A.
Andersson, C.
Verweij, N.
Holmes, M. V.
Ärnlöv, Johan, 1 ...
Svensson, P.
Hemingway, H.
Sallah, N.
Almgren, Peter
Aragam, K. G.
Asselin, G.
Backman, J. D.
Lind, Lars
Bloom, H. L.
Boersma, E.
Brandimarto, J.
Brown, M. R.
Brunner-La Rocca ...
Carey, D. J.
Chaffin, M. D.
Chasman, D. I.
Chazara, O.
Chen, X.
Chung, J. H.
Chutkow, W.
Cleland, J. G. F ...
Cook, J. P.
de Denus, S.
Dehghan, A.
Engström, Gunnar
Denaxas, S.
Doney, A. S.
Dorr, M.
Dudley, S. C.
Engstrom, G.
Esko, T.
Fatemifar, G.
Felix, S. B.
Finan, C.
Ford, I.
Fougerousse, F.
Fouodjio, R.
Ghanbari, M.
Ghasemi, S.
Giedraitis, Vilm ...
Giulianini, F.
Gottdiener, J. S ...
Gross, S.
Gudbjartsson, D. ...
Gui, H. S.
Gutmann, R.
Haggerty, C. M.
van der Harst, P ...
Helgadottir, A.
Hillege, H.
Hyde, C. L.
Smith, J. Gustav ...
Jukema, J. W.
Kamanu, F.
Kardys, I.
Kavousi, M.
Khaw, K. T.
Kleber, M. E.
Kober, L.
Koekemoer, A.
Kraus, B.
Kuchenbaecker, K ...
Langenberg, C.
Lind, L.
Lindgren, C. M.
London, B.
Lotta, L. A.
Lovering, R. C.
Luan, J. A.
Magnusson, P.
Mahajan, A.
Mann, D.
Margulies, K. B.
Marston, N. A.
Marz, W.
McMurray, J. J. ...
Melander, Olle
Melloni, G.
Mordi, I. R.
Perola, Markus
Morris, A. D.
Morris, A. P.
Morrison, A. C.
Nagle, M. W.
Nelson, C. P.
Newton-Cheh, C.
Niessner, A.
Niiranen, T.
Nowak, C.
O'Donoghue, M. L ...
Owens, A. T.
Palmer, C. N. A.
Pare, G.
Perola, M.
Perreault, L. P. ...
Portilla-Fernand ...
Psaty, B. M.
Rice, K. M.
Ridker, P. M.
Romaine, S. P. R ...
Roselli, C.
Rotter, J. I.
Ruff, C. T.
Sabatine, M. S.
Salo, P.
Salomaa, V.
van Setten, J.
Shalaby, A. A.
Smelser, D. T.
Smith, N. L.
Stefansson, K.
Stender, S.
Stott, D. J.
Sveinbjornsson, ...
Tammesoo, M. L.
Tardif, J. C.
Taylor, K. D.
Teder-Laving, M.
Teumer, A.
Thorgeirsson, G.
Thorsteinsdottir ...
Torp-Pedersen, C ...
Trompet, S.
Tuckwell, D.
Tyl, B.
Uitterlinden, A. ...
Vaura, F.
Veluchamy, A.
Visscher, P. M.
Volker, U.
Voors, A. A.
Wang, X. S.
Wareham, N. J.
Weeke, P. E.
Weiss, R.
White, H. D.
Wiggins, K. L.
Xing, H. M.
Yang, J.
Yang, Y. F.
Yerges-Armstrong ...
Yu, B.
Zannad, F.
Zhao, F. Y.
Wilk, J. B.
Holm, H.
Sattar, N.
Lubitz, S. A.
Lanfear, D. E.
Dunn, M. E.
Wells, Q. S.
Asselbergs, F. W ...
Hingorani, A. D.
Dube, M. P.
Samani, N. J.
Lang, C. C.
Cappola, T. P.
Ellinor, P. T.
Vasan, R. S.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Esc Heart Failur ...
By the university
University of Gothenburg
Uppsala University
Högskolan Dalarna
Lund University
Karolinska Institutet

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