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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Voight, Benjamin F. (author)
Scott, Laura J. (author)
Steinthorsdottir, Valgerdur (author)
show more...
Morris, Andrew P. (author)
Dina, Christian (author)
Welch, Ryan P. (author)
Zeggini, Eleftheria (author)
Huth, Cornelia (author)
Aulchenko, Yurii S. (author)
Thorleifsson, Gudmar (author)
McCulloch, Laura J. (author)
Ferreira, Teresa (author)
Grallert, Harald (author)
Amin, Najaf (author)
Wu, Guanming (author)
Willer, Cristen J. (author)
Raychaudhuri, Soumya (author)
McCarroll, Steve A. (author)
Langenberg, Claudia (author)
Hofmann, Oliver M. (author)
Dupuis, Josee (author)
Qi, Lu (author)
Segre, Ayellet V. (author)
van Hoek, Mandy (author)
Navarro, Pau (author)
Ardlie, Kristin (author)
Balkau, Beverley (author)
Benediktsson, Rafn (author)
Bennett, Amanda J. (author)
Blagieva, Roza (author)
Boerwinkle, Eric (author)
Bonnycastle, Lori L. (author)
Bostrom, Kristina Bengtsson (author)
Bravenboer, Bert (author)
Bumpstead, Suzannah (author)
Burtt, Noisel P. (author)
Charpentier, Guillaume (author)
Chines, Peter S. (author)
Cornelis, Marilyn (author)
Couper, David J. (author)
Crawford, Gabe (author)
Doney, Alex S. F. (author)
Elliott, Katherine S. (author)
Elliott, Amanda L. (author)
Erdos, Michael R. (author)
Fox, Caroline S. (author)
Franklin, Christopher S. (author)
Ganser, Martha (author)
Gieger, Christian (author)
Grarup, Niels (author)
Green, Todd (author)
Griffin, Simon (author)
Groves, Christopher J. (author)
Guiducci, Candace (author)
Hadjadj, Samy (author)
Hassanali, Neelam (author)
Herder, Christian (author)
Isomaa, Bo (author)
Jackson, Anne U. (author)
Johnson, Paul R. V. (author)
Jorgensen, Torben (author)
Kao, Wen H. L. (author)
Klopp, Norman (author)
Kong, Augustine (author)
Kraft, Peter (author)
Kuusisto, Johanna (author)
Lauritzen, Torsten (author)
Li, Man (author)
Lieverse, Aloysius (author)
Lindgren, Cecilia M. (author)
Lyssenko, Valeriya (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Marre, Michel (author)
Meitinger, Thomas (author)
Midthjell, Kristian (author)
Morken, Mario A. (author)
Narisu, Narisu (author)
Nilsson, Peter (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Owen, Katharine R. (author)
Payne, Felicity (author)
Perry, John R. B. (author)
Petersen, Ann-Kristin (author)
Platou, Carl (author)
Proenca, Christine (author)
Prokopenko, Inga (author)
Rathmann, Wolfgang (author)
Rayner, N. William (author)
Robertson, Neil R. (author)
Rocheleau, Ghislain (author)
Roden, Michael (author)
Sampson, Michael J. (author)
Saxena, Richa (author)
Shields, Beverley M. (author)
Shrader, Peter (author)
Sigurdsson, Gunnar (author)
Sparso, Thomas (author)
Strassburger, Klaus (author)
Stringham, Heather M. (author)
Sun, Qi (author)
Swift, Amy J. (author)
Thorand, Barbara (author)
Tichet, Jean (author)
Tuomi, Tiinamaija (author)
van Dam, Rob M. (author)
van Haeften, Timon W. (author)
van Herpt, Thijs (author)
van Vliet-Ostaptchouk, Jana V. (author)
Walters, G. Bragi (author)
Weedon, Michael N. (author)
Wijmenga, Cisca (author)
Witteman, Jacqueline (author)
Bergman, Richard N. (author)
Cauchi, Stephane (author)
Collins, Francis S. (author)
Gloyn, Anna L. (author)
Gyllensten, Ulf (author)
Uppsala universitet,Institutionen för genetik och patologi
Hansen, Torben (author)
Hide, Winston A. (author)
Hitman, Graham A. (author)
Hofman, Albert (author)
Hunter, David J. (author)
Hveem, Kristian (author)
Laakso, Markku (author)
Mohlke, Karen L. (author)
Morris, Andrew D. (author)
Palmer, Colin N. A. (author)
Pramstaller, Peter P. (author)
Rudan, Igor (author)
Sijbrands, Eric (author)
Stein, Lincoln D. (author)
Tuomilehto, Jaakko (author)
Uitterlinden, Andre (author)
Walker, Mark (author)
Wareham, Nicholas J. (author)
Watanabe, Richard M. (author)
Abecasis, Goncalo R. (author)
Boehm, Bernhard O. (author)
Campbell, Harry (author)
Daly, Mark J. (author)
Hattersley, Andrew T. (author)
Hu, Frank B. (author)
Meigs, James B. (author)
Pankow, James S. (author)
Pedersen, Oluf (author)
Wichmann, H-Erich (author)
Barroso, Ines (author)
Florez, Jose C. (author)
Frayling, Timothy M. (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Sladek, Rob (author)
Thorsteinsdottir, Unnur (author)
Wilson, James F. (author)
Illig, Thomas (author)
Froguel, Philippe (author)
van Duijn, Cornelia M. (author)
Stefansson, Kari (author)
Altshuler, David (author)
Boehnke, Michael (author)
McCarthy, Mark I. (author)
show less...
 (creator_code:org_t)
2010-06-27
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:7, s. 579-589
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Voight, Benjamin ...
Scott, Laura J.
Steinthorsdottir ...
Morris, Andrew P ...
Dina, Christian
Welch, Ryan P.
show more...
Zeggini, Elefthe ...
Huth, Cornelia
Aulchenko, Yurii ...
Thorleifsson, Gu ...
McCulloch, Laura ...
Ferreira, Teresa
Grallert, Harald
Amin, Najaf
Wu, Guanming
Willer, Cristen ...
Raychaudhuri, So ...
McCarroll, Steve ...
Langenberg, Clau ...
Hofmann, Oliver ...
Dupuis, Josee
Qi, Lu
Segre, Ayellet V ...
van Hoek, Mandy
Navarro, Pau
Ardlie, Kristin
Balkau, Beverley
Benediktsson, Ra ...
Bennett, Amanda ...
Blagieva, Roza
Boerwinkle, Eric
Bonnycastle, Lor ...
Bostrom, Kristin ...
Bravenboer, Bert
Bumpstead, Suzan ...
Burtt, Noisel P.
Charpentier, Gui ...
Chines, Peter S.
Cornelis, Marily ...
Couper, David J.
Crawford, Gabe
Doney, Alex S. F ...
Elliott, Katheri ...
Elliott, Amanda ...
Erdos, Michael R ...
Fox, Caroline S.
Franklin, Christ ...
Ganser, Martha
Gieger, Christia ...
Grarup, Niels
Green, Todd
Griffin, Simon
Groves, Christop ...
Guiducci, Candac ...
Hadjadj, Samy
Hassanali, Neela ...
Herder, Christia ...
Isomaa, Bo
Jackson, Anne U.
Johnson, Paul R. ...
Jorgensen, Torbe ...
Kao, Wen H. L.
Klopp, Norman
Kong, Augustine
Kraft, Peter
Kuusisto, Johann ...
Lauritzen, Torst ...
Li, Man
Lieverse, Aloysi ...
Lindgren, Cecili ...
Lyssenko, Valeri ...
Marre, Michel
Meitinger, Thoma ...
Midthjell, Krist ...
Morken, Mario A.
Narisu, Narisu
Nilsson, Peter
Owen, Katharine ...
Payne, Felicity
Perry, John R. B ...
Petersen, Ann-Kr ...
Platou, Carl
Proenca, Christi ...
Prokopenko, Inga
Rathmann, Wolfga ...
Rayner, N. Willi ...
Robertson, Neil ...
Rocheleau, Ghisl ...
Roden, Michael
Sampson, Michael ...
Saxena, Richa
Shields, Beverle ...
Shrader, Peter
Sigurdsson, Gunn ...
Sparso, Thomas
Strassburger, Kl ...
Stringham, Heath ...
Sun, Qi
Swift, Amy J.
Thorand, Barbara
Tichet, Jean
Tuomi, Tiinamaij ...
van Dam, Rob M.
van Haeften, Tim ...
van Herpt, Thijs
van Vliet-Ostapt ...
Walters, G. Brag ...
Weedon, Michael ...
Wijmenga, Cisca
Witteman, Jacque ...
Bergman, Richard ...
Cauchi, Stephane
Collins, Francis ...
Gloyn, Anna L.
Gyllensten, Ulf
Hansen, Torben
Hide, Winston A.
Hitman, Graham A ...
Hofman, Albert
Hunter, David J.
Hveem, Kristian
Laakso, Markku
Mohlke, Karen L.
Morris, Andrew D ...
Palmer, Colin N. ...
Pramstaller, Pet ...
Rudan, Igor
Sijbrands, Eric
Stein, Lincoln D ...
Tuomilehto, Jaak ...
Uitterlinden, An ...
Walker, Mark
Wareham, Nichola ...
Watanabe, Richar ...
Abecasis, Goncal ...
Boehm, Bernhard ...
Campbell, Harry
Daly, Mark J.
Hattersley, Andr ...
Hu, Frank B.
Meigs, James B.
Pankow, James S.
Pedersen, Oluf
Wichmann, H-Eric ...
Barroso, Ines
Florez, Jose C.
Frayling, Timoth ...
Groop, Leif
Sladek, Rob
Thorsteinsdottir ...
Wilson, James F.
Illig, Thomas
Froguel, Philipp ...
van Duijn, Corne ...
Stefansson, Kari
Altshuler, David
Boehnke, Michael
McCarthy, Mark I ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Other Clinical M ...
Articles in the publication
Nature Genetics
By the university
Uppsala University
Lund University

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