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Maternal Smoking in Pregnancy and Asthma in Preschool Children A Pooled Analysis of Eight Birth Cohorts
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- Neuman, Åsa (author)
- Karolinska Institutet,Uppsala universitet,Pediatrik,Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.
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- Hohmann, Cynthia (author)
- Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
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- Orsini, Nicola (author)
- Karolinska Institutet
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- Pershagen, Goran (author)
- Karolinska Institutet
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- Eller, Esben (author)
- Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark.;Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark.
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- Kjaer, Henrik Fomsgaard (author)
- Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, DK-5000 Odense, Denmark.
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- Gehring, Ulrike (author)
- Univ Utrecht, IRAS, Utrecht, Netherlands.
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- Granell, Raquel (author)
- Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
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- Henderson, John (author)
- Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
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- Heinrich, Joachim (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
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- Lau, Susanne (author)
- Charite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany.
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- Nieuwenhuijsen, Mark (author)
- Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain.
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- Sunyer, Jordi (author)
- Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain.;UPF, Barcelona, Spain.
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- Tischer, Christina (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
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- Torrent, Maties (author)
- CIBERESP, Barcelona, Spain.;Ib Salut, Area Salut Menorca, Palma De Mallorca, Spain.
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- Wahn, Ulrich (author)
- Charite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany.
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- Wijga, Alet H. (author)
- Natl Inst Publ Hlth & Environm RIVM, Ctr Prevent & Hlth Serv Res, Bilthoven, Netherlands.
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- Wickman, Magnus (author)
- Karolinska Institutet
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- Keil, Thomas (author)
- Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
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- Bergstrom, Anna (author)
- Karolinska Institutet
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the ENRICO, Consortium (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 186:10, s. 1037-1043
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Rationale: Although epidemiological studies suggest that exposure to maternal smoking during fetal and early life increases the risk of childhood wheezing and asthma, previous studies were not able to differentiate the effects of prenatal from postnatal exposure. Objectives: To assess the effect of exposure to maternal smoking only during pregnancy on wheeze and asthma among preschool-age children. Methods: A pooled analysis was performed based on individual participant data from eight European birth cohorts. Cohort-specific effects of maternal smoking during pregnancy, but not during the first year, on wheeze and asthma at 4 to 6 years of age were estimated using logistic regression and then combined using a random effects model. Adjustments were made for sex, parental education, parental asthma, birth weight, and siblings. Measurements and Main Results: Among the 21,600 children included in the analysis, 735 children (3.4%) were exposed to maternal smoking exclusively during pregnancy but not in the first year after birth. In the pooled analysis, maternal smoking only during pregnancy was associated with wheeze and asthma at 4 to 6 years of age, with adjusted odds ratios of 1.39 (95% confidence interval, 1.08-1.77) and 1.65 (95% confidence interval, 1.18-2.31), respectively. The likelihood to develop wheeze and asthma increased statistically significantly in a linear dose-dependent manner in relation to maternal daily cigarette consumption during the first trimester of pregnancy. Conclusions: Maternal smoking during pregnancy appears to increase the risk of wheeze and asthma among children who are not exposed to maternal smoking after birth.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- asthma
- cohort studies
- epidemiology
- preschool children
- tobacco smoking
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Neuman, Åsa
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Hohmann, Cynthia
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Orsini, Nicola
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Pershagen, Goran
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Eller, Esben
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Kjaer, Henrik Fo ...
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show more...
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Gehring, Ulrike
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Granell, Raquel
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Henderson, John
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Heinrich, Joachi ...
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Lau, Susanne
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Nieuwenhuijsen, ...
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Sunyer, Jordi
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Tischer, Christi ...
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Torrent, Maties
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Wahn, Ulrich
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Wijga, Alet H.
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Wickman, Magnus
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Keil, Thomas
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Bergstrom, Anna
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the ENRICO, Cons ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet